Krtap31-2 Inhibitors
Krtap31-2 inhibitors are a class of chemical compounds that interact with and inhibit the activity of keratin-associated protein 31-2 (Krtap31-2), a member of the large family of keratin-associated proteins (Krtaps). Krtaps are integral components of the keratinization process, particularly in the formation and maintenance of hair and nail structures in mammals. Keratin-associated proteins form disulfide linkages with keratin intermediate filaments, contributing to the mechanical properties of keratinized tissues. Krtap31-2 specifically plays a role in the stabilization and structural integrity of keratin fibers by facilitating crosslinking within the matrix, impacting the overall rigidity and resilience of these biological structures. Inhibiting Krtap31-2 can modulate these interactions, potentially altering the physical properties of keratin-based tissues.
The inhibition of Krtap31-2 generally occurs through the disruption of its binding sites or by interfering with its ability to form disulfide bonds, which are crucial for its function. Inhibitors can be small molecules designed to bind specific domains within the Krtap31-2 structure, preventing it from interacting with keratin or other associated proteins. This interference can lead to changes in the assembly of keratin fibers, which may alter their structural organization or reduce their mechanical strength. As with other protein inhibitors, Krtap31-2 inhibitors are often studied for their specificity and selectivity, as targeting such a specific protein requires a deep understanding of its structure and functional domains.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
A proteasome inhibitor disrupting the ubiquitin-proteasome system, potentially impacting Krtap31-2 by preventing its degradation and leading to altered protein turnover. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
A histone deacetylase inhibitor influencing chromatin remodeling, modulating Krtap31-2 gene expression by altering histone acetylation, subsequently affecting its transcriptional regulation. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
An autophagy inhibitor disrupting the autophagic process, potentially influencing Krtap31-2 by preventing its degradation through autophagy, leading to altered protein turnover and stability. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
An RNA polymerase inhibitor interfering with transcription, impacting Krtap31-2 gene expression by preventing RNA polymerase from initiating transcription, resulting in reduced mRNA levels and subsequent protein synthesis. | ||||||
MLN 4924 | 905579-51-3 | sc-484814 | 1 mg | $280.00 | 1 | |
A NEDD8-activating enzyme inhibitor disrupting the ubiquitin-proteasome system, potentially influencing Krtap31-2 degradation by preventing the activation of ubiquitin, leading to altered protein turnover and stability within the cell. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
A translation inhibitor disrupting protein synthesis, potentially impacting Krtap31-2 by preventing the translation of its mRNA, resulting in reduced protein levels and altered cellular functions associated with Krtap31-2. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
A histone deacetylase inhibitor influencing chromatin remodeling, modulating Krtap31-2 gene expression by altering histone acetylation, subsequently affecting its transcriptional regulation. | ||||||
Spliceostatin A | 391611-36-2 | sc-507481 | 1 mg | $1800.00 | ||
An RNA splicing inhibitor interfering with pre-mRNA processing, potentially impacting Krtap31-2 by altering its splicing pattern, leading to changes in the mature mRNA and subsequent protein isoforms, with potential functional consequences. | ||||||
Ginkgolic acid C15:1 | 22910-60-7 | sc-235249 | 5 mg | $306.00 | 2 | |
A SUMOylation inhibitor disrupting post-translational modification, potentially influencing Krtap31-2 by preventing SUMOylation, leading to altered protein stability, subcellular localization, and functional outcomes. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $88.00 $200.00 | 13 | |
A transcription factor inhibitor modulating gene expression, potentially impacting Krtap31-2 by interfering with the activity of transcription factors involved in its regulation, leading to changes in mRNA levels and subsequent alterations in protein expression. | ||||||