KRTAP12-2 Activators
KRTAP12-2 activators are chemical compounds that can increase the functional activity of KRTAP12-2, a protein known to be regulated by calcium levels. U73122, a phospholipase C inhibitor, enhances the availability of certain phospholipids, leading to an increase in KRTAP12-2 activity. Calcium modulators such as Thapsigargin, a SERCA inhibitor, Capsaicin, a vanilloid receptor agonist, and Carbachol, a cholinergic agonist, increase cytosolic calcium levels, leading to enhanced KRTAP12-2 activity. SKF96365, a non-selective inhibitor of receptor-mediated calcium entry, Ionomycin, a calcium ionophore, Nifedipine, a calcium channel blocker, Dantrolene, a ryanodine receptor antagonist, and Verapamil, an L-type calcium channel blocker, all modulate calcium levels, indirectly enhancing KRTAP12-2 activity.
Clopidogrel, a P2Y12 receptor antagonist, enhances KRTAP12-2 activity by increasing the availability of ADP, a known activator of KRTAP12-2. Lysophosphatidic Acid, a phospholipid derivative, and Fura-2/AM, a calcium indicator, can also enhance KRTAP12-2 activity. Lysophosphatidic Acid does so by activating G protein-coupled receptors, leading to increasedcalcium levels, while Fura-2/AM modulates calcium levels to indirectly enhance KRTAP12-2 activity.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin is a SERCA inhibitor, which enhances cytosolic calcium levels. KRTAP12-2 activity is influenced by calcium levels, and the increased cytosolic calcium can lead to enhanced KRTAP12-2 activity. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Capsaicin is a vanilloid receptor agonist that enhances calcium levels. As KRTAP12-2 activity is calcium-dependent, Capasaicin enhances KRTAP12-2 activity indirectly by increasing calcium levels. | ||||||
Carbachol | 51-83-2 | sc-202092 sc-202092A sc-202092C sc-202092D sc-202092B sc-202092E | 1 g 10 g 25 g 50 g 100 g 250 g | $122.00 $281.00 $388.00 $683.00 $1428.00 $3060.00 | 12 | |
Carbachol is a cholinergic agonist that enhances calcium levels. Increased calcium levels can enhance KRTAP12-2 activity. | ||||||
SK&F 96365 | 130495-35-1 | sc-201475 sc-201475B sc-201475A sc-201475C | 5 mg 10 mg 25 mg 50 mg | $103.00 $158.00 $397.00 $656.00 | 2 | |
SKF96365 is a non-selective inhibitor of receptor-mediated calcium entry. By modulating calcium levels, SKF96365 can indirectly enhance KRTAP12-2 activity. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $96.00 $264.00 | 2 | |
Ionomycin is a calcium ionophore that enhances intracellular calcium levels. As KRTAP12-2 activity is calcium-dependent, ionomycin can enhance KRTAP12-2 activity. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $59.00 $173.00 | 15 | |
Nifedipine is a calcium channel blocker that influences calcium availability. By modulating calcium levels, Nifedipine can indirectly enhance KRTAP12-2 activity. | ||||||
Dantrolene | 7261-97-4 | sc-500165 | 25 mg | $350.00 | 7 | |
Dantrolene is a ryanodine receptor antagonist that modulates calcium levels. By enhancing cytosolic calcium, Dantrolene can enhance KRTAP12-2 activity. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $374.00 | ||
Verapamil is an L-type calcium channel blocker that modulates calcium levels. By enhancing calcium availability, Verapamil can enhance KRTAP12-2 activity. | ||||||
S-(+)-Clopidogrel Hydrogen Sulfate | 120202-66-6 | sc-220001 sc-220001A sc-220001B | 100 mg 1 g 5 g | $84.00 $168.00 $571.00 | 1 | |
Clopidogrel is a P2Y12 receptor antagonist. By enhancing the availability of ADP, a known activator of KRTAP12-2, Clopidogrel can enhance KRTAP12-2 activity. | ||||||
Lysophosphatidic Acid | 325465-93-8 | sc-201053 sc-201053A | 5 mg 25 mg | $98.00 $341.00 | 50 | |
Lysophosphatidic Acid can enhance KRTAP12-2 activity by activating G protein-coupled receptors, leading to enhanced calcium levels. | ||||||