Klotho Activators
Klotho activators represent a diverse group of chemicals that modulate the expression of the Klotho protein, a key player in regulating various cellular processes. These chemicals exert their influence through distinct biochemical and cellular pathways, demonstrating the intricate regulatory network governing Klotho expression. One such class includes GSK-3β inhibitors, exemplified by Lithium chloride. By disrupting the β-catenin degradation complex in the Wnt pathway, Lithium chloride indirectly activates Klotho, as β-catenin regulates Klotho transcription. Another subset involves SIRT1 activators like Resveratrol and Piceatannol, which modulate the SIRT1/FOXO3a pathway. Activation of SIRT1 enhances Klotho expression, as FOXO3a, a downstream target, promotes Klotho transcription. Additionally, HDAC inhibitors like Sodium butyrate influence histone acetylation, indirectly activating Klotho by altering the chromatin structure around its gene promoter. These diverse pathways showcase the multifaceted nature of Klotho regulation by different classes of activators.
Epigenetic modifiers such as 5-Azacytidine contribute to Klotho activation by influencing DNA methylation patterns. As Klotho expression is subject to DNA methylation regulation, inhibiting DNA methyltransferases indirectly activates Klotho, underscoring the importance of epigenetic mechanisms in controlling Klotho levels. Meanwhile, compounds like N-Acetylcysteine act as ROS scavengers, indirectly activating Klotho by mitigating oxidative stress. Elevated ROS levels can suppress Klotho expression, making N-Acetylcysteine a crucial player in maintaining optimal Klotho levels. Thiazolidinediones, classified as PPARγ agonists, indirectly activate Klotho by modulating adipocyte differentiation and insulin sensitivity. The PPARγ pathway, when activated, has been associated with increased Klotho expression, emphasizing the intricate interplay between metabolic pathways and Klotho regulation. Additionally, the influence of Selenium compounds, exemplified by Sodium selenite, on selenoprotein expression indirectly activates Klotho, as Klotho itself is a selenoprotein. These examples highlight the nuanced and interconnected pathways through which Klotho activators exert their effects on Klotho expression.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride, a GSK-3β inhibitor, influences the Wnt pathway by disrupting the β-catenin degradation complex. This disturbance leads to increased β-catenin levels, which can indirectly activate Klotho expression, as β-catenin regulates Klotho transcription. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, a SIRT1 activator, modulates the SIRT1/FOXO3a pathway. The activation of SIRT1 can enhance Klotho expression since FOXO3a, a downstream target of SIRT1, promotes Klotho transcription. This chemical indirectly activates Klotho through the modulation of the SIRT1 pathway. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate, an HDAC inhibitor, can affect histone acetylation. This epigenetic modification can lead to increased Klotho expression as HDACs regulate the chromatin structure around the Klotho gene promoter, influencing its transcription. Sodium butyrate thus indirectly activates Klotho. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $34.00 $74.00 $270.00 $114.00 | 34 | |
N-Acetylcysteine, a ROS scavenger, influences the redox state in cells. Elevated ROS levels can suppress Klotho expression. By mitigating oxidative stress, N-Acetylcysteine indirectly activates Klotho, as the reduction in ROS levels can alleviate the inhibition of Klotho gene transcription. | ||||||
1,1-Dimethylbiguanide, Hydrochloride | 1115-70-4 | sc-202000F sc-202000A sc-202000B sc-202000C sc-202000D sc-202000E sc-202000 | 10 mg 5 g 10 g 50 g 100 g 250 g 1 g | $20.00 $43.00 $63.00 $156.00 $260.00 $510.00 $31.00 | 37 | |
Metformin, an AMPK activator, modulates cellular energy status. Activated AMPK can positively regulate Klotho expression, as AMPK can influence the mTOR pathway, which in turn affects Klotho transcription. Metformin thus indirectly activates Klotho through the modulation of AMPK signaling. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin, a PI3K/Akt pathway modulator, can activate Akt. Activated Akt has been linked to increased Klotho expression. By influencing the PI3K/Akt pathway, quercetin indirectly activates Klotho, as Akt can affect the expression of transcription factors involved in Klotho gene regulation. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane, a Nrf2 activator, influences antioxidant response elements. As Klotho is responsive to oxidative stress, sulforaphane can indirectly activate Klotho by promoting Nrf2-dependent antioxidant pathways, thereby enhancing the cellular environment for Klotho expression. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $44.00 $66.00 $204.00 $831.00 | 6 | |
Nicotinamide, an NAD+ precursor, influences sirtuin activity. Sirtuins, like SIRT1, can modulate pathways involved in Klotho expression. By affecting the NAD+/SIRT pathway, nicotinamide indirectly activates Klotho, as sirtuins play a role in regulating chromatin structure around the Klotho gene promoter. | ||||||
Sodium selenite | 10102-18-8 | sc-253595 sc-253595B sc-253595C sc-253595A | 5 g 500 g 1 kg 100 g | $49.00 $183.00 $316.00 $98.00 | 3 | |
Sodium selenite, a selenium compound, can influence selenoprotein expression. Klotho is a selenoprotein, and its expression can be positively regulated by selenium. Sodium selenite, therefore, indirectly activates Klotho by providing the necessary substrate for selenoprotein synthesis. | ||||||
Piceatannol | 10083-24-6 | sc-200610 sc-200610A sc-200610B | 1 mg 5 mg 25 mg | $51.00 $71.00 $199.00 | 11 | |
Piceatannol, a SIRT1 activator, can influence the SIRT1/FOXO3a pathway. Activation of SIRT1 by piceatannol may enhance Klotho expression, as FOXO3a, a downstream target of SIRT1, promotes Klotho transcription. Piceatannol thus indirectly activates Klotho through the modulation of the SIRT1 pathway. | ||||||