KLKb2 Activators
KLKb2 Activators are chemical compounds that, through various mechanisms, enhance the functional activity of KLKb2, a serine protease involved in the kallikrein-kinin system and coagulation pathways. For instance, Benzamidine, by inhibiting serine proteases that compete with KLKb2, enhances its proteolytic activity, ensuring that more substrate is available for KLKb2. Argatroban and D-Phe-Pro-Arg chloromethyl ketone (PPACK) serve as thrombin inhibitors, which indirectly increase KLKb2 activity by reducing thrombin's activation of protease-activated receptors, thereby decreasing competition for KLKb2 substrates. Similarly, Aprotinin, Nafamostat, and Gabexate are serine protease inhibitors that preserve KLKb2 activity by preventing degradation of KLKb2 or its substrates by other proteases. Corn trypsin inhibitor (CTI) modulates the contact pathway of blood coagulation, which can lead to an upsurge in KLKb2 activity by influencing the kallikrein-kinin system, while C1-Inhibitor regulates the complement system and contact system, potentially enhancing KLKb2 activity by limiting the activity of other proteases within these pathways.
KLKb2 Activators are a select group of chemical compounds that indirectly but specifically enhance the functional activity of the serine protease KLKb2. Within the intricate network of the coagulation and kallikrein-kinin systems, these activators work by inhibiting competing enzymes and modulating related pathways to favor KLKb2's proteolytic role. Benzamidine, for example, by selectively inhibiting other serine proteases, ensures that substrates are readily available for KLKb2, thereby enhancing its activity. Argatroban and D-Phe-Pro-Arg chloromethyl ketone (PPACK) reduce the activity of thrombin, which lessens PAR pathway signaling and, as a result, decreases substrate competition for KLKb2. Aprotinin, Nafamostat, and Gabexate, all serine protease inhibitors, protect KLKb2 from proteolytic degradation and prevent the depletion of its substrates, thus indirectly boosting its activity. Corn trypsin inhibitor (CTI) and C1-Inhibitor specifically target pathways that, when modulated, result in an upregulation of KLKb2 activity by altering the balance within the coagulation and complement systems.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Benzamidine | 618-39-3 | sc-233933 | 10 g | $286.00 | 1 | |
Competitive inhibitor of serine proteases; its use in low concentrations could enhance the functional activity of KLKb2 by preventing the binding of more potent endogenous inhibitors, thus indirectly increasing the availability of KLKb2 for its enzymatic function. | ||||||
Aprotinin | 9087-70-1 | sc-3595 sc-3595A sc-3595B | 10 mg 100 mg 1 g | $110.00 $400.00 $1615.00 | 51 | |
A serine protease inhibitor that in low concentrations may be used to selectively block competing serine proteases, which might result in a relative increase of KLKb2 activity due to reduced proteolytic competition. | ||||||
Phenylmethylsulfonyl Fluoride | 329-98-6 | sc-3597 sc-3597A | 1 g 100 g | $50.00 $683.00 | 92 | |
Irreversible inhibitor of serine proteases; at carefully controlled low concentrations could potentially increase the activity of KLKb2 by selectively inhibiting other serine proteases that would otherwise degrade or inactivate KLKb2. | ||||||
α-Iodoacetamide | 144-48-9 | sc-203320 | 25 g | $250.00 | 1 | |
Alkylating agent known to modify cysteine residues; when used in low concentrations, it could protect KLKb2 from unwanted cysteine modification, preserving its proteolytic activity. | ||||||
L-Lysine | 56-87-1 | sc-207804 sc-207804A sc-207804B | 25 g 100 g 1 kg | $93.00 $258.00 $519.00 | ||
Chloromethyl ketone that irreversibly inhibits trypsin-like serine proteases; used judiciously, it might enhance KLKb2 activity by reducing competition from other trypsin-like proteases. | ||||||
Bleomycin Sulfate | 9041-93-4 | sc-200134 sc-200134A sc-200134B sc-200134C | 10 mg 50 mg 100 mg 500 mg | $206.00 $612.00 $1020.00 $2856.00 | 38 | |
Serpin family inhibitor that targets chymotrypsin-like proteases; could indirectly enhance the activity of KLKb2 by shifting the balance of protease activity towards trypsin-like proteases, such as KLKb2, by inhibiting its competitors. | ||||||
Leupeptin hemisulfate | 103476-89-7 | sc-295358 sc-295358A sc-295358D sc-295358E sc-295358B sc-295358C | 5 mg 25 mg 50 mg 100 mg 500 mg 10 mg | $72.00 $145.00 $265.00 $489.00 $1399.00 $99.00 | 19 | |
Inhibitor of various proteases, including serine proteases; low-dose leupeptin may reduce the activity of proteases that degrade KLKb2, leading to an increase in the active form of KLKb2 in the local environment. | ||||||
E-64 | 66701-25-5 | sc-201276 sc-201276A sc-201276B | 5 mg 25 mg 250 mg | $275.00 $928.00 $1543.00 | 14 | |
Irreversible cysteine protease inhibitor; while it does not directly activate KLKb2, it could lead to an accumulation of substrates that are preferentially cleaved by KLKb2, effectively enhancing its functional role in proteolysis. | ||||||