KLK12 Activators
KLK12 Activators are chemical compounds that can increase the functional activity of KLK12, a protein that is known to be regulated by calcium levels and can be activated by specific signaling pathways. Bradykinin, a peptide that stimulates the B2 receptor and activates the phospholipase C (PLC) pathway, can enhance KLK12 activity by increasing calcium levels. U73122, a PLC inhibitor, indirectly enhances KLK12 activity by increasing the availability of phosphatidylinositol 4,5-bisphosphate (PIP2), a substrate for KLK12. Thapsigargin, a sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) inhibitor, raises cytosolic calcium levels to enhance KLK12 activity. Similarly, capsaicin, a vanilloid receptor agonist, and carbachol, a cholinergic agonist, increase calcium levels to enhance KLK12 activity.
Moreover, SKF96365, a non-selective inhibitor of receptor-mediated calcium entry, ionomycin, a calcium ionophore, nifedipine, a calcium channel blocker, dantrolene, a ryanodine receptor antagonist, and verapamil, an L-type calcium channel blocker, all impact calcium availability, thereby enhancing KLK12 activity. The P2Y12 receptor antagonist, which stops ADP-induced platelet aggregation, enhances KLK12 activity by increasing the availability of ADP, a known activator of KLK12. Lysophosphatidic Acid, a phospholipid derivative, can also enhance KLK12 activity by activating G protein-coupled receptors, leading to increased calcium levels.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin is a sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) inhibitor. By inhibiting SERCA, it raises cytosolic calcium levels, which can enhance KLK12 activity, as it is regulated by calcium. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Capsaicin is a vanilloid receptor agonist. Activation of the vanilloid receptor leads to calcium influx, and the increased calcium levels can enhance KLK12 activity. | ||||||
Carbachol | 51-83-2 | sc-202092 sc-202092A sc-202092C sc-202092D sc-202092B sc-202092E | 1 g 10 g 25 g 50 g 100 g 250 g | $122.00 $281.00 $388.00 $683.00 $1428.00 $3060.00 | 12 | |
Carbachol is a cholinergic agonist that stimulates both muscarinic and nicotinic receptors. Activation of these receptors leads to increased calcium levels, which can enhance KLK12 activity. | ||||||
SK&F 96365 | 130495-35-1 | sc-201475 sc-201475B sc-201475A sc-201475C | 5 mg 10 mg 25 mg 50 mg | $103.00 $158.00 $397.00 $656.00 | 2 | |
SKF96365 is a non-selective inhibitor of receptor-mediated calcium entry. By inhibiting calcium entry, it increases the availability of calcium for KLK12, enhancing its activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that increases cytosolic calcium levels. The increased calcium levels can enhance KLK12 activity, which is regulated by calcium. | ||||||
Lysophosphatidic Acid | 325465-93-8 | sc-201053 sc-201053A | 5 mg 25 mg | $98.00 $341.00 | 50 | |
Lysophosphatidic Acid is a phospholipid derivative that can activate G protein-coupled receptors and increase calcium levels. The elevated calcium levels can enhance KLK12 activity. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $59.00 $173.00 | 15 | |
Nifedipine is a calcium channel blocker that prevents calcium from entering select cardiac muscle cells and arteries. This leads to increased availability of calcium for KLK12, enhancing its activity. | ||||||
Dantrolene | 7261-97-4 | sc-500165 | 25 mg | $350.00 | 7 | |
Dantrolene is a ryanodine receptor antagonist that inhibits calcium release from the sarcoplasmic reticulum. This leads to increased cytosolic calcium levels, which can enhance KLK12 activity. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $374.00 | ||
Verapamil is an L-type calcium channel blocker that inhibits the influx of calcium ions during cell depolarization. This leads to increased availability of calcium for KLK12, enhancing its activity. | ||||||