KIR2DL1 Inhibitors
KIR2DL1 inhibitors are a class of chemical compounds designed to specifically target and modulate the activity of the Killer Cell Immunoglobulin-like Receptor 2DL1 (KIR2DL1) protein. KIR2DL1 is a cell surface receptor primarily found on natural killer (NK) cells, a type of immune cell involved in the body's defense against infected or cancerous cells. This receptor plays a crucial role in regulating NK cell function by binding to specific ligands on target cells. By interacting with these ligands, KIR2DL1 can either inhibit or activate NK cell activity, depending on the context. KIR2DL1 inhibitors are developed with the aim of selectively blocking the inhibitory signaling pathway mediated by KIR2DL1, thereby enhancing NK cell activation and the immune response against target cells.
The design and development of KIR2DL1 inhibitors involve identifying small molecules or peptides that can bind to KIR2DL1 and disrupt its interaction with its ligands. These inhibitors are typically designed to be highly specific to KIR2DL1, minimizing off-target effects on other immune receptors or cells. By interfering with the inhibitory signaling of KIR2DL1, these inhibitors have the potential to enhance the immune system's ability to recognize and eliminate infected or cancerous cells, making them of interest in various research contexts. Understanding the precise mechanisms of KIR2DL1 inhibition and its effects on NK cell function is crucial for advancing our knowledge of immune regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $63.00 $92.00 $250.00 $485.00 $1035.00 $2141.00 | 69 | |
Cyclosporin A is an immunosuppressive drug that inhibits the activity of calcineurin, thereby impeding the production of interleukin-2 (IL-2). As IL-2 enhances the cytotoxic activity of NK cells, inhibiting its production can indirectly affect KIR2DL1 signaling. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits mTOR (mechanistic target of rapamycin), leading to a reduction in protein synthesis, including the synthesis of cytokines such as IL-2 that enhance NK cell activity. This can indirectly impact KIR2DL1. | ||||||
FK-506 | 104987-11-3 | sc-24649 sc-24649A | 5 mg 10 mg | $78.00 $151.00 | 9 | |
FK506 inhibits calcineurin, leading to a reduction in IL-2 production. This can indirectly impact KIR2DL1 by reducing the activation of NK cells. | ||||||
Mycophenolic acid | 24280-93-1 | sc-200110 sc-200110A | 100 mg 500 mg | $69.00 $266.00 | 8 | |
Mycophenolic acid inhibits inosine monophosphate dehydrogenase, leading to a reduction in guanine nucleotide synthesis and subsequently a reduction in DNA and RNA synthesis. This can indirectly affect KIR2DL1 by reducing NK cell proliferation. | ||||||
Prednisone | 53-03-2 | sc-205816 sc-205816A sc-205816B | 1 g 5 g 25 g | $42.00 $136.00 $676.00 | 2 | |
Steroids inhibit the production of various cytokines and chemokines that are involved in immune cell activation. This can indirectly affect KIR2DL1 by reducing NK cell activity. | ||||||
Azathioprine | 446-86-6 | sc-210853D sc-210853 sc-210853A sc-210853B sc-210853C | 500 mg 1 g 2 g 5 g 10 g | $203.00 $176.00 $349.00 $505.00 $704.00 | 1 | |
Azathioprine is an immunosuppressive drug that inhibits DNA synthesis, thereby reducing the proliferation of immune cells. This can indirectly inhibit KIR2DL1 by reducing NK cell proliferation. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
Methotrexate inhibits dihydrofolate reductase, leading to a reduction in DNA synthesis. This can indirectly affect KIR2DL1 by reducing NK cell proliferation. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
Hydroxyurea inhibits ribonucleotide reductase, leading to a reduction in DNA synthesis. This can indirectly affect KIR2DL1 by reducing NK cell proliferation. | ||||||
6-Mercaptopurine | 50-44-2 | sc-361087 sc-361087A | 50 mg 100 mg | $72.00 $104.00 | ||
6-Mercaptopurine inhibits purine synthesis, leading to a reduction in DNA and RNA synthesis. This can indirectly affect KIR2DL1 by reducing NK cell proliferation. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
Fluorouracil is a pyrimidine analogue that inhibits DNA synthesis. This can indirectly affect KIR2DL1 by reducing NK cell proliferation. | ||||||