KIF4 Activators
The first group of chemicals, which includes Taxol and Epothilone B, enhances KIF4's activity by stabilizing microtubules. KIF4 is a kinesin protein that relies on microtubules to transport cellular cargo. By stabilizing the microtubules, these compounds increase the efficiency of KIF4's transport activity, thereby enhancing its function.
A second group of compounds, including Nocodazole, Vinblastine, Colchicine, Combretastatin A4, Podophyllotoxin, Estramustine, 2-methoxyestradiol, Maytansine, Noscapine, and Albendazole, works differently. These compounds disrupt microtubule dynamics, either by destabilizing microtubules or by inhibiting their assembly. While this may seem counterintuitive, it is important to note that in cellular systems, destabilization of microtubules can paradoxically enhance the activity of kinesin proteins like KIF4. This is because the disruption of microtubules increases the demand for KIF4's cargo transport activity to maintain cellular homeostasis. As a result, these compounds indirectly enhance the activity of KIF4 by increasing its functional demand within the cell.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Taxol is a drug that stabilizes microtubules and prevents their disassembly, which is integral for the function of KIF4. By stabilizing the microtubules, Taxol enhances the activity of KIF4, a kinesin motor protein, as it relies on microtubules as tracks for transport. | ||||||
Epothilone B, Synthetic | 152044-54-7 | sc-203944 | 2 mg | $176.00 | ||
Epothilone B is a microtubule-stabilizing compound. KIF4 is a kinesin protein that relies on microtubules to transport cellular cargo. By stabilizing microtubules, Epothilone B enhances the functional activity of KIF4. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Nocodazole is an agent that disrupts microtubule dynamics. While this may initially seem counterproductive, the resulting microtubule destabilization can paradoxically enhance the activity of some kinesin proteins like KIF4. This is because the disruption of microtubules can increase the demand for KIF4's cargo transport activity to maintain cellular homeostasis. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $100.00 $230.00 $450.00 $1715.00 $2900.00 | 4 | |
Vinblastine is a microtubule-destabilizing agent. Similar to Nocodazole, the destabilization of microtubules by Vinblastine can enhance KIF4's activity by increasing the demand for cargo transport along the microtubules. | ||||||
Combrestatin A4 | 117048-59-6 | sc-204697 sc-204697A | 1 mg 5 mg | $45.00 $79.00 | ||
Combrestatin A4 is a microtubule-destabilizing agent. The disruption of microtubules by this compound increases the need for KIF4's activity in cargo transport, thereby enhancing its function. | ||||||
Podophyllotoxin | 518-28-5 | sc-204853 | 100 mg | $82.00 | 1 | |
Podophyllotoxin is a toxin that inhibits microtubule assembly. The resulting increase in demand for KIF4's cargo transport activity enhances its function. | ||||||
Estramustine | 2998-57-4 | sc-353281 sc-353281A | 100 mg 1 g | $265.00 $743.00 | ||
Estramustine is a drug that binds to microtubule-associated proteins (MAPs) and disrupts microtubule dynamics. This increases the demand for KIF4's activity in cargo transport, therefore enhancing its function. | ||||||
2-Methoxyestradiol | 362-07-2 | sc-201371 sc-201371A | 10 mg 50 mg | $70.00 $282.00 | 6 | |
2-methoxyestradiol is a natural metabolite of estradiol that disrupts microtubules. It increases the demand for the KIF4's cargo transport activity, hence enhancing its function. | ||||||
Maytansine | 35846-53-8 | sc-507510 | 100 mg | $1000.00 | ||
Maytansine is a potent microtubule-destabilizing agent. The disruption of microtubules by this compound increases the need for KIF4's activity in cargo transport, thereby enhancing its function. | ||||||
Noscapine | 128-62-1 | sc-219418 | 10 mg | $102.00 | ||
Noscapine is an agent that alters microtubule dynamics. The resulting increase in demand for KIF4's cargo transport activity enhances its function. | ||||||