KIAA1530 Inhibitors
The class of chemicals known as KIAA1530 Inhibitors mainly encompasses compounds that target various aspects of DNA repair or DNA damage response pathways. Given UVSSA's role in transcription-coupled nucleotide excision repair (TC-NER), the compounds listed can indirectly influence its functional contributions to DNA repair. These inhibitors often target key enzymes involved in DNA repair processes, such as topoisomerases, DNA-PK, ATM, and ATR kinases, PARP, and others.
By inhibiting these enzymes, the chemicals disrupt the proper functioning of DNA repair pathways, thereby indirectly affecting the proteins, including UVSSA, involved in these pathways. For instance, topoisomerase inhibitors like camptothecin and etoposide induce DNA breaks and by inhibiting the repair of these breaks, indirectly modulate the functional roles of proteins implicated in DNA repair. Similarly, PARP inhibitors such as olaparib prevent the repair of single-strand breaks, which can escalate to double-strand breaks if not repaired. As the cell's repair machinery attempts to address these lesions, proteins like UVSSA are indirectly influenced.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
Topoisomerase I inhibitor which generates DNA single-strand breaks, disrupting DNA repair processes in which UVSSA may be involved. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Topoisomerase II inhibitor. By introducing DNA breaks and hindering their repair, the function of proteins like UVSSA can be indirectly affected. | ||||||
Olaparib | 763113-22-0 | sc-302017 sc-302017A sc-302017B | 250 mg 500 mg 1 g | $210.00 $305.00 $495.00 | 10 | |
PARP inhibitor that hinders base excision repair. UVSSA's role in DNA repair might be influenced when PARP-mediated repair is compromised. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
HDAC inhibitor. Histone modification affects DNA repair, potentially modulating the DNA repair functions of proteins like UVSSA. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
DNA methyltransferase inhibitor which alters DNA methylation, potentially influencing the DNA repair mechanisms associated with UVSSA. | ||||||
ATM Kinase Inhibitor | 587871-26-9 | sc-202963 | 2 mg | $110.00 | 28 | |
Inhibits ATM kinase, a major DNA damage response protein, potentially modulating DNA repair processes involving UVSSA. | ||||||
NU 7441 | 503468-95-9 | sc-208107 | 5 mg | $357.00 | 10 | |
DNA-PK inhibitor which affects non-homologous end joining, potentially influencing the functional aspects of UVSSA in DNA repair. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
PI3K and DNA-PK inhibitor. By targeting DNA-PK, it can influence DNA repair pathways where UVSSA is potentially involved. | ||||||
UCN-01 | 112953-11-4 | sc-202376 | 500 µg | $251.00 | 10 | |
Inhibits Chk1, a kinase involved in DNA damage checkpoint. Can indirectly modulate DNA repair processes involving UVSSA. | ||||||
Aphidicolin | 38966-21-1 | sc-201535 sc-201535A sc-201535B | 1 mg 5 mg 25 mg | $84.00 $306.00 $1104.00 | 30 | |
DNA polymerase α inhibitor, blocking DNA replication and thus affecting DNA repair processes and proteins like UVSSA. | ||||||