KIAA1257 Inhibitors

Cilia and flagella associated protein 92, also known as CFAP92, is a protein thought to be involved in the structure and function of cilia and flagella. Cilia and flagella are hair-like structures that protrude from the surface of many eukaryotic cells. While flagella are typically involved in cell locomotion and are usually longer and fewer in number, cilia can be either motile or non-motile, serving various functions from fluid movement to sensory roles.CFAP92 is characterized as a member of the CFAP family due to its association with these cellular appendages. Though specific functions of CFAP92 may not be fully elucidated, proteins in this family generally play critical roles in the assembly, maintenance, and proper functioning of cilia and flagella. Mutations in genes encoding ciliary and flagellar proteins can lead to a spectrum of disorders known as ciliopathies, which can affect multiple organ systems, including the respiratory system, reproductive system, kidneys, and nervous system, reflecting the diverse functions of cilia in different cell types.

In terms of structure, CFAP92 is likely to contain domains that facilitate its integration into the ciliary or flagellar architecture, potentially interacting with microtubules, the central scaffold of these organelles, or with other ciliary proteins. Its exact location within the cilia or flagella, be it the axoneme, basal body, or transition zone, and the precise nature of its interactions with other proteins in these structures, remain areas for further investigation.Given the "putative" label often assigned to CFAP92, it implies that while there is evidence suggestive of its role in ciliary and flagellar function, additional research is warranted to fully confirm its activities and mechanisms. Advanced studies involving proteomics, molecular biology, and genetics are essential to clarify the role of CFAP92 and its impact on ciliary and flagellar biogenesis and function.