KIAA0841 Inhibitors
Chemical inhibitors of KIAA0841 can impact its function through various mechanisms involving the disruption or stabilization of microtubules. Paclitaxel and laulimalide, for example, stabilize microtubules, which adversely affects the role of KIAA0841 in regulating microtubule dynamics. This stabilization prevents the normal disassembly of microtubules, essential for the dynamic processes in which KIAA0841 is involved. Similarly, peloruside A functions by locking the microtubules in a polymerized state, thus impeding the ability of KIAA0841 to manage the delicate balance of microtubule assembly and disassembly. On the other hand, colchicine and 2-Methoxyestradiol bind to tubulin, the building block of microtubules, thereby inhibiting their polymerization. This action results in a functional inhibition of KIAA0841 due to the disruption of the microtubule structures that KIAA0841 regulates.
In addition to these agents, other chemicals like nocodazole and vinblastine target microtubule assembly by interacting with tubulin. Nocodazole binds to β-tubulin and hinders its polymerization, leading to microtubule network collapse, which in turn inhibits the function of KIAA0841 in microtubule assembly. Vinblastine also prevents microtubule formation by binding tubulin, directly impairing the role of KIAA0841 in microtubule-based processes. Vincristine, another tubulin-binding compound, disrupts microtubule assembly, which is crucial for the proper function of KIAA0841, especially during cell division. Podophyllotoxin and maytansine similarly inhibit the polymerization of tubulin into microtubules, which in turn hinders the function of KIAA0841 in cell division and microtubule dynamics. Lastly, griseofulvin interacts with polymerized microtubules, causing disruption of mitotic spindles, which would impede the role of KIAA0841 in spindle dynamics during cell division. Eribulin, by binding to microtubule plus ends, sequesters tubulin monomers and inhibits their polymerization, yet another way in which the activity of KIAA0841 can be inhibited.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Paclitaxel stabilizes microtubules and as a result can inhibit the function of KIAA0841, as this protein is involved in the regulation of microtubule dynamics. By preventing microtubule disassembly, paclitaxel can disrupt the normal functioning of KIAA0841 in the microtubule organization. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $98.00 $315.00 $2244.00 $4396.00 $17850.00 $34068.00 | 3 | |
Colchicine binds to tubulin, one of the main constituents of microtubules, thereby inhibiting microtubule polymerization. As KIAA0841 is associated with microtubule dynamics, the action of colchicine would lead to a functional inhibition of KIAA0841 by disrupting the microtubules that KIAA0841 is known to interact with and regulate. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Nocodazole is a synthetic compound that disrupts microtubule networks by binding to β-tubulin and inhibiting its polymerization. KIAA0841, being a protein associated with microtubule assembly, would be inhibited in its function due to the collapse of the microtubule structure that nocodazole induces. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $100.00 $230.00 $450.00 $1715.00 $2900.00 | 4 | |
Vinblastine interferes with microtubule assembly by binding tubulin, thereby inhibiting microtubule formation. Since KIAA0841 plays a role in microtubule-based processes, the inhibition of microtubule assembly by vinblastine would directly impair the functional role of KIAA0841. | ||||||
Podophyllotoxin | 518-28-5 | sc-204853 | 100 mg | $82.00 | 1 | |
Podophyllotoxin binds to tubulin and inhibits its polymerization into microtubules, thereby disrupting the microtubule network. As KIAA0841 is involved in the stabilization and organization of microtubules, the action of podophyllotoxin would lead to an inhibition of KIAA0841's function in cell division and microtubule dynamics. | ||||||
Eribulin | 253128-41-5 | sc-507547 | 5 mg | $865.00 | ||
Eribulin binds to microtubule plus ends, causing sequestration of tubulin monomers and inhibition of their polymerization. This would inhibit KIAA0841 by preventing proper microtubule formation and function, which is essential for the protein's role in cell division and intracellular transport. | ||||||
Griseofulvin | 126-07-8 | sc-202171A sc-202171 sc-202171B | 5 mg 25 mg 100 mg | $83.00 $216.00 $586.00 | 4 | |
Griseofulvin disrupts microtubule function by interacting with polymerized microtubules and disrupting mitotic spindles. This would functionally inhibit KIAA0841 by impairing the microtubule structures that KIAA0841 is known to associate with, thereby affecting its role in spindle dynamics during cell division. | ||||||
Laulimalide | 115268-43-4 | sc-507261 | 100 µg | $200.00 | ||
Laulimalide acts by stabilizing microtubules and can inhibit the function of KIAA0841 by locking microtubules in a polymerized state, thus preventing the dynamic instability required for proper KIAA0841 function in microtubule organization. | ||||||
Maytansine | 35846-53-8 | sc-507510 | 100 mg | $1000.00 | ||
Maytansine binds to tubulin at the rhizoxin binding site and inhibits its polymerization into microtubules, which would inhibit the function of KIAA0841 by disrupting microtubule dynamics and the protein's role in cell division and spindle formation. | ||||||