KIAA0841 Activators
KIAA0841 Activators are a collection of chemical compounds that indirectly enhance the functional activity of KIAA0841 through distinct signaling pathways. For instance, Forskolin and 8-Bromo-cAMP both increase cAMP levels, which in turn activate PKA, a kinase that can phosphorylate substrates involved in the pathways where KIAA0841 operates, leading to its enhanced activity. Similarly, Ionomycin and A23187 raise intracellular calcium concentrations, which can activate calcium-dependent protein kinases that may act on KIAA0841 or its associated proteins, thus promoting its functional role. PMA, a PKC activator, and Epigallocatechin gallate (EGCG), a kinase inhibitor, both contribute to KIAA0841's activation by affecting signaling networks that KIAA0841 is part of, through phosphorylation and inhibition of competitive signaling, respectively.
Furthermore, the activity of KIAA0841 is influenced by chemicals that modulate phosphatase activity and intracellular calcium signaling. Okadaic acid, by inhibiting phosphatases PP1 and PP2A, increases phosphorylation levels within KIAA0841's signaling pathways, indirectly enhancing its activity. Thapsigargin and Calmodulin antagonists such as W-7 lead to changes in calcium dynamics, with thapsigargin increasing calcium levels by inhibiting the SERCA pump and W-7 disrupting calmodulin-mediated processes, both potentially leading to the activation of pathways involving KIAA0841. Additionally, small molecule inhibitors like LY294002, U0126, and SB203580 shift cellular signaling dynamics by inhibiting the PI3K/AKT, MEK/ERK, and p38 MAPK pathways, respectively. This inhibition can lead to a compensatory upregulation of alternative signaling routes that enhance the function of KIAA0841, thereby highlighting the intricate interplay between these activators and the cellular pathways that govern KIAA0841's activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, leading to an increase in cyclic AMP (cAMP) levels. Elevated cAMP activates protein kinase A (PKA), which can phosphorylate various substrates. This cascade can enhance the functional activity of KIAA0841 through cAMP-responsive elements binding protein (CREB)-mediated transcriptional activation. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium concentration. KIAA0841, being sensitive to calcium signaling, is functionally activated as calcium-dependent protein kinases can modify proteins that interact with or regulate KIAA0841. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC). PKC activation can lead to phosphorylation of proteins that are part of KIAA0841's signaling network, thereby enhancing KIAA0841's functional activities. | ||||||
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $106.00 $166.00 $289.00 $550.00 $819.00 | 2 | |
8-Bromo-cAMP is a cell-permeable cAMP analog that activates PKA. Activation of PKA can lead to phosphorylation events that alter the activity of proteins within KIAA0841's signaling framework, resulting in enhanced function. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic acid is an inhibitor of protein phosphatases PP1 and PP2A. This can lead to increased phosphorylation levels of proteins within KIAA0841's signaling pathways, indirectly enhancing KIAA0841's activity due to reduced dephosphorylation. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin is a SERCA pump inhibitor that elevates intracellular calcium levels. Elevated calcium can activate calcium/calmodulin-dependent kinases, which may regulate proteins interacting with KIAA0841, thus enhancing its activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a known inhibitor of various kinases. By inhibiting competitive kinases, signaling pathways that favor KIAA0841's activation may become more predominant, leading to enhanced activity. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is a calcium ionophore that increases intracellular calcium levels. This can activate calcium-dependent signaling pathways, enhancing the activity of proteins that regulate or are regulated by KIAA0841. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that alters AKT signaling. By inhibiting PI3K/AKT pathway, other pathways might be upregulated, which could include those that activate KIAA0841. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a MEK inhibitor that impacts the MAPK/ERK pathway. Inhibition of MEK could result in a compensatory activation of alternative signaling pathways, potentially enhancing KIAA0841's activity. | ||||||