KCTD10 Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $92.00 $204.00 | 19 | |
Cyclopamine inhibits the Hedgehog (Hh) signaling pathway by binding to and inhibiting Smoothened (Smo), which is essential for Hh pathway activation. Given KCTD10's role in the noncanonical Hh pathway, the inhibition of Smo would decrease pathway activity, contributing to a decrease in KCTD10's functional participation in the pathway. | ||||||
GANT61 | 500579-04-4 | sc-202630 sc-202630A sc-202630B | 1 mg 5 mg 10 mg | $63.00 $128.00 $200.00 | 6 | |
GANT61 acts as a specific inhibitor of the glioma-associated oncogene (GLI) transcription factors in the Hedgehog pathway. By preventing GLI-mediated transcription, it indirectly reduces the functional activity of KCTD10, which is associated with the noncanonical Hedgehog signaling. | ||||||
Jervine | 469-59-0 | sc-200934 sc-200934A | 1 mg 5 mg | $66.00 $240.00 | 1 | |
Jervine functions similarly to cyclopamine by inhibiting Smoothened in the Hedgehog signaling pathway. This inhibition can reduce the activity of the pathway, thereby diminishing the role of KCTD10 in this context. | ||||||
Vismodegib | 879085-55-9 | sc-396759 sc-396759A | 10 mg 25 mg | $80.00 $96.00 | 1 | |
Vismodegib is a Smoothened antagonist that inhibits the Hedgehog signaling pathway. By disrupting Smo, KCTD10's role in the pathway would be indirectly inhibited due to the decreased pathway activity. | ||||||
Erismodegib | 956697-53-3 | sc-396280 sc-396280A | 10 mg 100 mg | $255.00 $918.00 | ||
Sonidegib inhibits Smoothened in the Hedgehog pathway. By curtailing Smo activity, the Hedgehog pathway's function is diminished, which in turn would lead to an indirect inhibition of KCTD10's role in the pathway. | ||||||
SANT-1 | 304909-07-7 | sc-203253 | 5 mg | $132.00 | 5 | |
SANT1 is a potent antagonist of Smoothened. Inhibition of Smo by SANT1 would lead to a decrease in Hedgehog signaling, thereby causing an indirect inhibition of KCTD10's role within this pathway. | ||||||
U 18666A | 3039-71-2 | sc-203306 sc-203306A | 10 mg 50 mg | $140.00 $500.00 | 2 | |
U18666A is an inhibitor of cholesterol transport and can disrupt the trafficking and function of Smoothened in the Hedgehog pathway, thereby causing an indirect inhibition of KCTD10's role within the pathway. | ||||||