JAM-A Activators
Common JAM-A Activators include, but are not limited to D-erythro-Sphingosine-1-phosphate CAS 26993-30-6, Rosiglitazone CAS 122320-73-4, Simvastatin CAS 79902-63-9, PGE2 CAS 363-24-6 and Forskolin CAS 66575-29-9.
JAM-A, or Junctional Adhesion Molecule A, is a protein integral to tight junctions in epithelial and endothelial cells, which are critical for establishing and maintaining cell polarity and tissue integrity. JAM-A is involved in a variety of cellular processes including cell-cell adhesion, paracellular permeability, and cellular migration. It has been identified as playing a crucial role in the maintenance of tight junctions and the regulation of barrier function in epithelial tissues. Furthermore, JAM-A has been observed to have interactions with various proteins, including integrins and other tight junction-associated proteins, which influence its role in cell signaling and cellular dynamics.
The chemical class of JAM-A Activators consists of compounds formulated to augment the activity or expression of JAM-A. By enhancing the functional capacity of JAM-A, these activators can fortify cell-cell junctions, bolstering the integrity of epithelial and endothelial barriers. An upregulated JAM-A activity could lead to enhanced cell-cell adhesion, which might result in a more robust barrier function in tissues where JAM-A is prominently expressed. Moreover, since JAM-A is instrumental in several cellular signaling pathways, its activators could modulate various cellular responses linked to JAM-A's interactions and signaling roles. The intricacies of JAM-A's functionality, coupled with the modulation by its activators, underline the importance of understanding the molecular and cellular implications of such compounds. This knowledge can pave the way for exploring novel avenues in cell biology, tissue engineering, and understanding the fundamental aspects of cellular adhesion and signaling.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
S1P is known to modulate tight junction integrity in endothelial cells and may influence the expression of tight junction proteins, including JAM-A. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $118.00 $320.00 $622.00 $928.00 $1234.00 | 38 | |
As PPARγ agonists, thiazolidinediones can influence gene expression in endothelial cells and may affect JAM-A expression. | ||||||
Simvastatin | 79902-63-9 | sc-200829 sc-200829A sc-200829B sc-200829C | 50 mg 250 mg 1 g 5 g | $30.00 $87.00 $132.00 $434.00 | 13 | |
Statins have pleiotropic effects on endothelial function and may influence the expression of adhesion molecules, potentially including JAM-A. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
PGE2 is involved in inflammation and vascular permeability and might influence JAM-A expression in endothelial cells. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Elevated cAMP levels can lead to the modulation of tight junction proteins' expression, potentially influencing JAM-A. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which can influence tight junction dynamics and potentially JAM-A expression. | ||||||