Date published: 2026-2-14

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ITM2A Inhibitors

The term ITM2A inhibitors refers to a class of chemical compounds that specifically target and inhibit the activity of ITM2A, also known as Integral Membrane Protein 2A. ITM2A is a transmembrane protein that plays a crucial role in various cellular processes, including cell adhesion, signal transduction, and cellular differentiation. The inhibitors belonging to this class are designed to modulate the function of ITM2A through various mechanisms. Structurally, ITM2A inhibitors are diverse and can be small molecules or larger compounds. They interact with specific binding sites on the ITM2A protein, interfering with its normal functioning or blocking its activity altogether. The inhibition of ITM2A can lead to downstream effects on cellular pathways that involve this protein, impacting cellular processes such as cell proliferation, migration, and apoptosis.

Researchers and scientists explore ITM2A inhibitors as valuable tools to better understand the function of ITM2A within cells and its implications in various biological processes. Through studying the effects of these inhibitors, researchers aim to elucidate the intricate mechanisms underlying ITM2A-related cellular events. The development of ITM2A inhibitors involves rigorous testing and optimization to ensure their specificity and effectiveness. Chemists employ structure-activity relationship studies to identify key chemical moieties responsible for binding to ITM2A and modulating its activity. This knowledge guides the design of new compounds with improved potency and selectivity. Additionally, understanding ITM2A inhibition may have implications in fields beyond disease research. By manipulating ITM2A activity, researchers may gain insights into fundamental cellular processes that could contribute to advancements in areas like tissue engineering, regenerative medicine, and cellular reprogramming.

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

BMS-906024

1401066-79-2sc-507372
10 mg
$3600.00
(0)

Directly interacts with ITM2A, inhibiting its function and affecting cell proliferation pathways involved in oncogenesis.

PF-3084014

1290543-63-3sc-507501
5 mg
$130.00
(0)

Specifically inhibits ITM2A activity as part of its dual action against Notch signaling and ITM2A-mediated pathways.

RO-4929097

847925-91-1sc-364602
sc-364602A
10 mg
50 mg
$439.00
$1417.00
1
(1)

Indirectly inhibits ITM2A through gamma-secretase inhibition, affecting multiple signaling pathways including those involving ITM2A.

Compound E

209986-17-4sc-221433
sc-221433A
sc-221433B
250 µg
1 mg
5 mg
$124.00
$342.00
$967.00
12
(2)

Indirectly inhibits ITM2A as part of its action within the Notch signaling pathway, affecting neurodegenerative diseases and oncology research.

Semagacestat

425386-60-3sc-364614
sc-364614A
10 mg
50 mg
$350.00
$1200.00
1
(0)

Indirectly affects ITM2A function as part of its broader action against amyloid-beta production pathways.

BMS-708163

1146699-66-2sc-364444
sc-364444A
10 mg
50 mg
$480.00
$1455.00
1
(0)

Indirectly inhibits ITM2A through its role as a gamma-secretase inhibitor, with implications for ITM2A-mediated pathways.

MK-0752

471905-41-6sc-364534
sc-364534A
10 mg
50 mg
$592.00
$1550.00
(1)

Influences ITM2A function indirectly as a gamma-secretase inhibitor, focusing on modifying cancer therapy progression pathways.