Islet-2 Activators
Islet-2 activators belong to a distinct chemical class within the realm of bioactive compounds that hold significant relevance in the field of molecular biology and cellular physiology. These molecules are characterized by their specific ability to modulate the activity of Islet-2, a transcription factor predominantly found in pancreatic beta cells. Islet-2, also known as Isl2, is a member of the LIM-homeodomain (LIM-HD) family of transcription factors, which are vital for the development and maintenance of various tissues and organs during embryogenesis and postnatal life.
Islet-2 activators typically exert their influence by binding to specific regulatory elements or domains within the Islet-2 protein, thereby enhancing its transcriptional activity and promoting gene expression. This activation is critical for the proper functioning of pancreatic beta cells, as Islet-2 plays a pivotal role in regulating the expression of genes involved in insulin production and secretion. Consequently, Islet-2 activators are of particular interest in the context of understanding the molecular mechanisms governing glucose homeostasis and the intricate signaling pathways that underlie insulin release.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid is a form of vitamin A and acts as a ligand for retinoic acid receptors (RARs). It can activate Islet-2 by binding to RARs, which may regulate gene expression. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is a natural compound that increases intracellular cAMP levels. It activates Islet-2 by stimulating cAMP-responsive gene expression. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a phorbol ester that activates protein kinase C (PKC), potentially affecting Islet-2 expression through PKC-mediated signaling. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone, a synthetic glucocorticoid, activates Islet-2 through glucocorticoid receptor-mediated mechanisms that affect gene expression. | ||||||