Date published: 2026-2-22

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ISG12a Activators

ISG12a Activators encompass a specific group of chemical compounds that are tailored to target and activate the ISG12a protein. ISG12a, part of the larger family of Interferon-Stimulated Genes (ISGs), plays a notable role in cellular responses to various stimuli, particularly those related to immune signaling. ISGs, including ISG12a, are typically upregulated in response to interferon signaling, a key aspect of the immune response, especially in antiviral defense mechanisms. ISG12a has been identified as having a significant role in these processes, although the complete scope of its functions and interactions within the cell is still a subject of ongoing research. ISG12a Activators are designed to interact directly with the ISG12a protein, potentially altering its conformation, stability, or its interaction with other cellular components. This interaction is crucial as it can modulate the natural behavior and activity of ISG12a within the cell, impacting the cellular response to immune signaling.

The study of ISG12a Activators is particularly relevant in molecular biology and immunology due to the integral role of ISG12a in immune-related cellular processes. These activators are usually small molecular compounds that bind to specific sites on the ISG12a protein, leading to changes in its activity. The mechanism by which these activators exert their influence largely depends on their chemical structure and the nature of their interaction with ISG12a. By binding to ISG12a, these activators can alter how the protein functions, potentially affecting its ability to interact with other cellular components, including receptors and signaling molecules involved in the immune response. This can lead to a cascade of reactions within the cell, altering various cellular processes related to immune signaling and response. Research in this field is focused on understanding the complex network of protein interactions in cells and the role of specific proteins like ISG12a in these networks. Insights gained from the study of ISG12a Activators contribute to a broader understanding of the molecular mechanisms that underlie the regulation of immune responses and the intricate interplay of signaling pathways in cells.

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Polyinosinic acid - polycytidylic acid sodium salt, double-stranded

42424-50-0sc-204854
sc-204854A
10 mg
100 mg
$139.00
$663.00
2
(1)

Poly(I:C) is a synthetic analog of double-stranded RNA that can mimic viral infection, potentially inducing interferon pathways.

Imiquimod

99011-02-6sc-200385
sc-200385A
100 mg
500 mg
$67.00
$284.00
6
(1)

Imiquimod acts as an agonist of Toll-like receptor 7, which can lead to the activation of interferon signaling.

R-848

144875-48-9sc-203231
sc-203231A
sc-203231B
sc-203231C
5 mg
25 mg
100 mg
500 mg
$102.00
$306.00
$510.00
$1559.00
12
(1)

Similar to Imiquimod, Resiquimod engages Toll-like receptor 7/8, potentially stimulating interferon responses.

Gardiquimod

1020412-43-4sc-221663
sc-221663A
sc-221663B
sc-221663C
sc-221663D
sc-221663E
sc-221663F
25 mg
50 mg
100 mg
250 mg
5 g
10 g
25 g
$157.00
$282.00
$516.00
$1177.00
$20138.00
$32779.00
$70753.00
1
(1)

Gardiquimod is a selective TLR7 agonist that may induce type I interferon production and related gene expressions.

Loxoribine

121288-39-9sc-203118
sc-203118A
25 mg
100 mg
$124.00
$390.00
1
(0)

Acting on TLR7, Loxoribine is a guanosine analog that could induce the interferon signaling pathway.

Brefeldin A

20350-15-6sc-200861C
sc-200861
sc-200861A
sc-200861B
1 mg
5 mg
25 mg
100 mg
$31.00
$53.00
$124.00
$374.00
25
(3)

Brefeldin A can induce cellular stress responses, potentially affecting ISG expression.

Amlexanox

68302-57-8sc-217630
10 mg
$160.00
2
(1)

Originally an anti-inflammatory, Amlexanox may have effects on cellular signaling pathways involved in the immune response.