Molecular structure of Loxoribine, CAS Number: 121288-39-9
Loxoribine (CAS 121288-39-9)
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Alternate Names:
7-Allyl-7,8-dihydro-8-oxoguanosine
Application:
Loxoribine is agonist for TLR7 (Toll-like receptor 7)
CAS Number:
121288-39-9
Purity:
≥97%
Molecular Weight:
339.3
Molecular Formula:
C13H17N5O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Loxoribine is a selective agonist for TLR7 (Toll-like receptor 7) via IFN. Activates natural killer cells and primes cytolytic precursor cells for activation by IL-2. Loxoribine is a very potent immunostimulatory compound that increases cytokine production and possesses antitumor and antiviral properties.
Loxoribine (CAS 121288-39-9) References
- Cytotoxic combination of loxoribine with fludarabine and mafosfamide on freshly isolated B-chronic lymphocytic leukemia cells. | Pellacani, A., et al. 1999. Leuk Lymphoma. 33: 147-53. PMID: 10194132
- Recognition of pathogen-associated molecular patterns by TLR family. | Akira, S. and Hemmi, H. 2003. Immunol Lett. 85: 85-95. PMID: 12527213
- Engagement of TLR3, TLR7, and NKG2D regulate IFN-gamma secretion but not NKG2D-mediated cytotoxicity by human NK cells stimulated with suboptimal doses of IL-12. | Girart, MV., et al. 2007. J Immunol. 179: 3472-9. PMID: 17804388
- Loxoribine, a selective Toll-like receptor 7 agonist, induces maturation of human monocyte-derived dendritic cells and stimulates their Th-1- and Th-17-polarizing capability. | Dzopalic, T., et al. 2010. Int Immunopharmacol. 10: 1428-33. PMID: 20817120
- Loxoribine pretreatment reduces Salmonella Enteritidis organ invasion in 1-day-old chickens. | Swaggerty, CL., et al. 2012. Poult Sci. 91: 1038-42. PMID: 22399745
- Activation of Toll-like receptor 7 provides cardioprotection in septic cardiomyopathy-induced systolic dysfunction. | Saiyang, X., et al. 2021. Clin Transl Med. 11: e266. PMID: 33463061
- CD163+ M2 Macrophages Promote Fibrosis in IgG4-Related Disease Via Toll-like Receptor 7/Interleukin-1 Receptor-Associated Kinase 4/NF-κB Signaling. | Chinju, A., et al. 2022. Arthritis Rheumatol. 74: 892-901. PMID: 34907668
- Conjugation with loxoribine and mannan improves the immunogenicity of Mycobacterium tuberculosis CFP10-TB10.4 fusion protein. | Yu, W., et al. 2022. Eur J Pharm Biopharm. 172: 193-202. PMID: 35183715
- A new approach to vaccine adjuvants. Immunopotentiation by intracellular T-helper-like signals transmitted by loxoribine. | Goodman, MG. 1995. Pharm Biotechnol. 6: 581-609. PMID: 7551237
- The immunostimulatory compound 7-allyl-8-oxoguanosine (loxoribine) induces a distinct subset of murine cytokines. | Pope, BL., et al. 1995. Cell Immunol. 162: 333-9. PMID: 7743561
- Murine strain variation in the natural killer cell and proliferative responses to the immunostimulatory compound 7-allyl-8-oxoguanosine: role of cytokines. | Pope, BL., et al. 1994. Cell Immunol. 159: 194-210. PMID: 7994754
- 7-Allyl-8-oxoguanosine (loxoribine) inhibits the metastasis of B16 melanoma cells and has adjuvant activity in mice immunized with a B16 tumor vaccine. | Pope, BL., et al. 1994. Cancer Immunol Immunother. 38: 83-91. PMID: 8306370
Activator of:
DDX60L, IFI-205, IFITM7, IFIX, IFN-α16, IFN-α9, IFN-β, IFN-ω, Il-28a, ISG12a, Mx2, OTTMUSG00000007655, OTTMUSG00000011275, TAP, TLR1, TLR3, and TLR7.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Loxoribine, 25 mg | sc-203118 | 25 mg | $124.00 | |||
Loxoribine, 100 mg | sc-203118A | 100 mg | $390.00 |