IRBP Activators
Retinol-binding protein 3 Activators are a diverse set of chemical compounds that enhance the visual cycle function by increasing the bioavailability of retinol or by supporting ocular health, which indirectly leads to the improved functional activity of Retinol-binding protein 3. Retinoic acid, Fenretinide, Isotretinoin, and Tretinoin, being derivatives or analogs of vitamin A, directly augment the availability of retinol, Retinol-binding protein 3's primary ligand, and thus facilitate the protein's role in the visual cycle. Retinol-binding protein 3 Activators encompass compounds that indirectly potentiate the visual cycle function by enhancing the availability of retinol or by sustaining ocular health, which in turn facilitates the improved functional activity of Retinol-binding protein 3. Retinoic acid, Fenretinide, Isotretinoin, and Tretinoin, as derivatives or analogs of vitamin A, directly increase the pool of retinol, the primary ligand for Retinol-binding protein 3, thus enabling its essential role in the visual cycle. Similarly, Vitamin A palmitate serves as a direct source of retinol, ensuring an adequate supply for the protein's function.
Carotenoids like β-Carotene, Lycopene, Canthaxanthin, and Zeaxanthin, though not all directly converted to vitamin A, contribute to the retinol levels or support eye health, which could indirectly enhance Retinol-binding protein 3's activity. Citral can augment the synthesis of retinaldehyde, adding to the retinol reserves, while compounds like Astaxanthin, though not vitamin A precursors, promote a healthy retinal environment that is conducive to the visual cycle's efficiency. The biochemical pathways influenced by these activators collectively ensure that Retinol-binding protein 3 can effectively bind and transport retinol, a crucial component of the visual cycle. Desmosterol, as a cholesterol biosynthesis precursor, has a suggested role in retinoid storage and release, potentially modulating the availability of retinol to augment Retinol-binding protein 3's function.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid influences retinoid signaling pathways, which are implicated in visual processing. This compound enhances the functional activity of Retinol-binding protein 3 by increasing the availability of retinol, its ligand, thereby facilitating its role in the visual cycle. | ||||||
13-cis-Retinoic acid | 4759-48-2 | sc-205568 sc-205568A | 100 mg 250 mg | $74.00 $118.00 | 8 | |
Isotretinoin, a retinoid, is known to impact retinoid signaling. It indirectly enhances Retinol-binding protein 3's function by modulating the levels of retinol and related metabolites, which are crucial for vision. | ||||||
β-Carotene | 7235-40-7 | sc-202485 sc-202485A sc-202485B sc-202485C | 1 g 25 g 50 g 5 kg | $68.00 $297.00 $502.00 $12246.00 | 5 | |
β-Carotene is a precursor to vitamin A and upon conversion indirectly enhances the activity of Retinol-binding protein 3 by increasing the pool of retinol, which is bound by the protein to facilitate visual function. | ||||||
Citral | 5392-40-5 | sc-252620 | 1 kg | $212.00 | ||
Citral is a compound that can enhance the synthesis of retinaldehyde, a form of vitamin A. This synthesis indirectly enhances the activity of Retinol-binding protein 3 by providing a consistent supply of retinol for the visual cycle. | ||||||
Lycopene | 502-65-8 | sc-205738 sc-205738A sc-205738B | 1 mg 5 mg 1 g | $143.00 $571.00 $6125.00 | 4 | |
Lycopene, a carotenoid, can be enzymatically cleaved to yield retinoids. This indirect action enhances the functional activity of Retinol-binding protein 3 by contributing to the pool of retinol that the protein binds and transports as part of the visual cycle. | ||||||
Zeaxanthin | 144-68-3 | sc-205544 sc-205544A | 500 µg 1 mg | $265.00 $454.00 | 5 | |
Zeaxanthin, one of the carotenoids, while not directly converted to retinol, supports overall eye health and could indirectly support Retinol-binding protein 3 function by maintaining the integrity of retinal tissue and potentially facilitating the visual cycle. | ||||||
Desmosterol | 313-04-2 | sc-214871 sc-214871A | 5 mg 10 mg | $92.00 $162.00 | 1 | |
Desmosterol is a precursor in cholesterol biosynthesis and has been suggested to influence retinoid storage and release. By impacting these processes, it could indirectly enhance the activity of Retinol-binding protein 3 by modulating the availability of retinol in the visual cycle. | ||||||