Integrin VIb Activators
Integrin VIb, a notable protein in the integrin family, is pivotal in the intricate dance of cellular interactions and the adhesive dynamics essential for structural organization within tissues. This protein facilitates the union between cells and the extracellular matrix, playing a crucial role in the transduction of signals that orchestrate cellular behavior in response to environmental cues. The expression of Integrin VIb is a tightly regulated process, influenced by a symphony of molecular signals that ensure its presence is fine-tuned to the needs of the cell and its surrounding tissue matrix. Understanding the factors that induce the expression of Integrin VIb is fundamental to comprehending the complex regulatory networks that govern cell adhesion, migration, and the maintenance of tissue integrity.
In the quest to delineate the activators of Integrin VIb expression, several chemical compounds have emerged as potential candidates. Compounds such as 1,25-Dihydroxyvitamin D3 and all-trans Retinoic Acid are thought to engage with nuclear receptors, subsequently initiating a cascade of transcriptional events that lead to the upregulation of this integrin. Similarly, Forskolin, recognized for its ability to elevate intracellular cAMP levels, may indirectly contribute to the amplification of Integrin VIb synthesis through the activation of downstream kinases. Moreover, the intricate interplay of intracellular pathways influenced by compounds like Genistein or Resveratrol suggests that alterations in signaling can translate into increased expression of this protein. The nuances of these molecular interactions underscore the complexity of cellular regulation and the potential for diverse chemicals to serve as activators, each working through unique mechanisms to stimulate the production of Integrin VIb, thereby ensuring the cells' capacity to communicate and adhere to their extracellular milieu is maintained.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
1α,25-Dihydroxyvitamin D3 | 32222-06-3 | sc-202877B sc-202877A sc-202877C sc-202877D sc-202877 | 50 µg 1 mg 5 mg 10 mg 100 µg | $325.00 $632.00 $1428.00 $2450.00 $400.00 | 32 | |
May upregulate Integrin VIb by binding to vitamin D receptors, which then interact with vitamin D response elements in the promoter regions of the target genes, enhancing transcription and possibly leading to increased Integrin VIb synthesis in immune cells and various epithelial cells. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Could induce Integrin VIb expression through the activation of retinoic acid receptors, which bind to retinoic acid response elements in gene promoters, stimulating the transcription of genes involved in cellular differentiation and development where Integrin VIb plays a critical role. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
May stimulate Integrin VIb expression by acting as a tyrosine kinase inhibitor, thereby altering cellular signaling pathways that govern cell growth and adhesion, potentially leading to increased Integrin VIb on the cell surface of various tissues. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Could increase Integrin VIb levels by activating adenylyl cyclase, leading to a rise in intracellular cAMP, which subsequently activates protein kinase A (PKA) and enhances the transcription of genes, including those coding for Integrin VIb involved in cell-to-extracellular matrix interactions. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
May stimulate the expression of Integrin VIb by acting as a diacylglycerol analog, activating protein kinase C (PKC) isoforms, which then phosphorylate transcription factors that enhance gene expression, including that of adhesion molecules such as Integrin VIb. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
Could induce the expression of Integrin VIb by inhibiting DNA methyltransferases, leading to the hypomethylation of gene promoters and the reactivation of silenced genes, potentially including those encoding for integrins involved in cell adhesion and migration. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
May upregulate Integrin VIb expression through its antioxidative action, which can activate a cascade of signaling pathways leading to the enhanced transcription of genes that govern cellular adhesion and tissue repair mechanisms. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Could stimulate the transcription of Integrin VIb by inhibiting the activation of transcription factors such as NF-κB, which is involved in the inflammatory response, thereby potentially promoting the expression of genes that aid in wound healing and cell adhesion. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
May increase Integrin VIb expression by acting as a histone deacetylase inhibitor, leading to an open chromatin structure and enhanced accessibility of transcriptional machinery to the promoters of genes coding for cell adhesion molecules. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Could induce the expression of Integrin VIb by disrupting the GSK-3β signaling pathway, thereby stabilizing β-catenin, which can translocate to the nucleus and activate Wnt target genes, including those related to Integrin VIb expression in neuronal and other tissues. | ||||||