ILVBL Inhibitors
ILVBL inhibitors are a class of chemicals that interact with various specific signaling pathways or biological processes to decrease the functional activity of ILVBL. For example, LY294002 targets PI3Ks within the AKT/mTOR signaling pathway. Since this pathway is crucial for regulating protein synthesis and cell survival, the inhibition by LY294002 would compromise the stability or localization required for ILVBL function. Similarly, rapamycin acts on mTOR, a key component in cell growth and proliferation processes; its inhibition can reduce protein synthesis rates, which could, in turn, reduce ILVBL's activity if it is reliant on this pathway for its function.
Further, dasatinib inhibits Src kinase activity, potentially disrupting signaling complexes or pathways necessary for ILVBL's function, while PD98059, a MEK inhibitor, can affect the MAPK/ERK pathway, potentially leading to decreased ILVBL activity if it relies on this pathway. Tofacitinib and cyclosporineILVBL inhibitors are a class of chemicals that interact with various specific signaling pathways or biological processes to decrease the functional activity of ILVBL. For example, LY294002 targets PI3Ks within the AKT/mTOR signaling pathway. Since this pathway is crucial for regulating protein synthesis and cell survival, the inhibition by LY294002 would compromise the stability or localization required for ILVBL function. Similarly, rapamycin acts on mTOR, a key component in cell growth and proliferation processes; its inhibition can reduce protein synthesis rates, which could, in turn, reduce ILVBL's activity if it is reliant on this pathway for its function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a specific inhibitor of phosphoinositide 3-kinases (PI3Ks). Given that PI3Ks are involved in the AKT/mTOR signaling pathway, which regulates protein synthesis and cell survival, inhibition of PI3K can indirectly inhibit ILVBL function by disrupting the pathway that is necessary for ILVBL's stability or localization within the cell. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is an mTOR inhibitor. ILVBL's activity, if it is linked to cell growth and proliferation processes regulated by the mTOR pathway, could be inhibited. By decreasing the overall protein synthesis rates, rapamycin could indirectly reduce the functional activity of ILVBL. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $70.00 $145.00 | 51 | |
Dasatinib is a Src kinase inhibitor. Src kinases are involved in various signaling pathways that regulate cell proliferation and survival. Inhibition of Src kinase could, therefore, disrupt signaling complexes or pathways that are necessary for ILVBL's function. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is a MEK inhibitor, which prevents the activation of the MAPK/ERK pathway. ILVBL may require MAPK/ERK signaling for its activation or interaction with other signaling molecules. Inhibition of this pathway could lead to a decrease in ILVBL functional activity. | ||||||
Cyclosporine | 79217-60-0 | sc-358111 sc-358111A | 100 mg 1 g | $195.00 $1012.00 | 2 | |
Cyclosporine is a calcineurin inhibitor that impedes the activation of NFAT transcription factors. If ILVBL's function or expression is regulated through NFAT-mediated gene expression, inhibition of calcineurin could lead to a decrease in ILVBL activity. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Bortezomib is a proteasome inhibitor which can lead to an accumulation of ubiquitinated proteins and subsequent cellular stress. If ILVBL's function is linked to the degradation of specific proteins, inhibition of the proteasome could indirectly inhibit its activity. | ||||||
SB-216763 | 280744-09-4 | sc-200646 sc-200646A | 1 mg 5 mg | $71.00 $202.00 | 18 | |
SB216763 is a GSK-3 inhibitor that disrupts Wnt/β-catenin signaling. If ILVBL is modulated by GSK-3 activity, its inhibition could lead to a decrease in ILVBL's functional activity. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $374.00 | ||
Verapamil is an L-type calcium channel blocker that reduces calcium influx. If ILVBL function is calcium-dependent, its activity could be indirectly inhibited by the reduced intracellular calcium levels. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $28.00 $53.00 | 37 | |
2-APB inhibits IP3 receptors and TRP channels, which are involved in intracellular calcium release and influx. If ILVBL's function is calcium signaling-dependent, inhibition of these channels could indirectly lead to a reduction in ILVBL activity. | ||||||