IKK Inhibitors
Items 11 to 14 of 14 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-(5,6-dimethoxy-1H-benzimidazol-1-yl)-3-[[4-(methylsulfonyl)phenyl]methoxy]-2-thiophenecarboxamide | 916985-21-2 | sc-205128 sc-205128A | 1 mg 5 mg | $46.00 $228.00 | ||
5-(5,6-dimethoxy-1H-benzimidazol-1-yl)-3-[[4-(methylsulfonyl)phenyl]methoxy]-2-thiophenecarboxamide acts as an IKK inhibitor by engaging in specific hydrogen bonding and hydrophobic interactions within the enzyme's active site. Its unique structural features facilitate selective binding, leading to a significant alteration in downstream signaling pathways. The compound's stability in various pH environments enhances its potential for prolonged activity, while its lipophilicity aids in cellular penetration and localization. | ||||||
Hypoestoxide, Hypoestes rosea | 88498-46-8 | sc-221735 | 1 mg | $208.00 | ||
Hypoestoxide, derived from Hypoestes rosea, functions as an IKK inhibitor through its distinctive molecular architecture, which promotes effective π-π stacking and van der Waals interactions with the enzyme. This compound exhibits a remarkable ability to modulate protein conformations, thereby influencing critical signaling cascades. Its robust stability across diverse biochemical conditions, coupled with its unique electronic properties, enhances its interaction dynamics within cellular environments. | ||||||
Anandamide | 94421-68-8 | sc-396321 sc-396321A sc-396321B sc-396321C | 5 mg 25 mg 500 mg 1 g | $81.00 $219.00 $4068.00 $7813.00 | 2 | |
Anandamide, a naturally occurring fatty acid amide, acts as an IKK inhibitor by engaging in specific hydrophobic interactions and hydrogen bonding with the enzyme's active site. Its unique structure allows for conformational flexibility, facilitating dynamic binding and modulation of IKK activity. The compound's lipid-like properties enable it to traverse cellular membranes efficiently, influencing intracellular signaling pathways and promoting nuanced regulatory effects on inflammation and stress responses. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $81.00 $306.00 | 32 | |
Parthenolide, a sesquiterpene lactone, functions as an IKK inhibitor through its ability to form covalent bonds with cysteine residues in the IKK complex. This selective interaction disrupts the kinase's activity, altering downstream signaling pathways. Its unique stereochemistry enhances binding affinity, while its lipophilic nature aids in membrane permeability, allowing for effective cellular uptake and modulation of key inflammatory responses. The compound's reactivity and specificity contribute to its role in cellular regulation. | ||||||