IGLON5 Inhibitors
IGLON5 inhibitors encompass a range of chemical compounds that indirectly affect the functional activity of IGLON5 by targeting various biochemical and cellular pathways. For instance, Hydrogen Sulfide and 2,4-Dinitrophenol disrupt the mitochondrial electron transport chain and oxidative phosphorylation, respectively, leading to a reduction in ATP production. Since neuronal protein functions, including those of IGLON5, are highly energy-dependent, reduced ATP levels can significantly diminish IGLON5's functional activity. Similarly, compounds such as Lithium and Fluoride impact intracellular signaling pathways, such as the IP3-dependent calcium signaling and GPCR-mediated cAMP pathways, respectively. These signaling pathways are crucial for maintaining the physiological states that are necessary for IGLON5's activity, and their disruption can result in a decrease in IGLON5 function.
On the other hand, compounds like Chlorpromazine and Wortmannin target specific signaling receptors and kinases that are indirectly associated with IGLON5 function. Chlorpromazine decreases dopamine signaling, which may lead to diminished cAMP levels and indirectly inhibit IGLON5 through altered phosphorylation states. Wortmannin interferes with the PI3K/Akt pathway, which is integral to neuronal survival and plasticity, and its inhibition could reduce the signaling environment that supports IGLON5 activity. Further, Rapamycin and Cyclopiazonic Acid impede mTOR signaling and SERCA function, respectively, affecting synaptic protein synthesis and calcium-dependent signaling pathways; both are vital for maintaining IGLON5's functional integrity.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium influences the inositol monophosphatase enzyme, leading to a depletion of inositol triphosphate (IP3). This depletion affects the IP3-dependent calcium signaling, which is essential for the proper functioning of neuronal proteins, potentially reducing the activity of IGLON5 by altering intracellular calcium levels. | ||||||
Copper(II) sulfate | 7758-98-7 | sc-211133 sc-211133A sc-211133B | 100 g 500 g 1 kg | $45.00 $120.00 $185.00 | 3 | |
Copper(II) sulfate can interfere with cellular signaling pathways by promoting oxidative stress. The oxidative environment can affect the function of membrane proteins, including IGLON5, by modifying their structure or the lipid environment they are embedded in. | ||||||
Chlorpromazine | 50-53-3 | sc-357313 sc-357313A | 5 g 25 g | $60.00 $108.00 | 21 | |
Chlorpromazine is a dopamine antagonist that can decrease dopamine receptor activity. Reduced dopamine signaling can lead to decreased cAMP levels, which may indirectly inhibit proteins such as IGLON5 by altering their phosphorylation states and function. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits the mTOR pathway, which is essential for protein synthesis and autophagy regulation. Inhibition of mTOR can lead to reduced synaptic protein synthesis, potentially lowering the functional levels of synaptic proteins like IGLON5. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is an inhibitor of phosphoinositide 3-kinases (PI3K), leading to suppression of the Akt signaling pathway. This suppression can indirectly inhibit proteins involved in neuronal survival and plasticity, such as IGLON5, by impairing their signaling environment. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $98.00 $315.00 $2244.00 $4396.00 $17850.00 $34068.00 | 3 | |
Colchicine binds to tubulin, inhibiting microtubule polymerization. This disruption of the cytoskeleton can impair intracellular transport mechanisms, potentially reducing the trafficking and surface expression of membrane proteins like IGLON5. | ||||||
Cyclopiazonic Acid | 18172-33-3 | sc-201510 sc-201510A | 10 mg 50 mg | $173.00 $612.00 | 3 | |
Cyclopiazonic acid inhibits the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA), leading to depletion of calcium stores. This depletion can disrupt calcium-dependent signaling pathways, potentially inhibiting the function of proteins like IGLON5. | ||||||
2,4-Dinitrophenol, wetted | 51-28-5 | sc-238345 | 250 mg | $58.00 | 2 | |
2,4-Dinitrophenol uncouples oxidative phosphorylation, leading to decreased ATP production. Reduced ATP availability can impair the energy-dependent processes required for the proper functioning of neuronal proteins, including IGLON5. | ||||||