IgE Inhibitors

IgE inhibitors as a chemical class encompass a range of compounds that indirectly modulate the production or function of IgE antibodies. These inhibitors primarily target the cellular and molecular pathways associated with IgE-mediated immune responses, particularly allergic reactions. The primary role of these compounds is not to inhibit IgE directly, but to influence the immune system's response that involves IgE. This is achieved through various mechanisms, such as stabilizing mast cells (e.g., Cromolyn Sodium, Ketotifen), modulating leukotriene activity (e.g., Montelukast, Zileuton), or providing anti-inflammatory effects (e.g., Quercetin, Curcumin).

These compounds function in diverse pathways of the immune system. Mast cell stabilizers prevent the release of histamine and other mediators from mast cells, which are crucial in IgE-mediated allergic responses. Leukotriene modifiers like Montelukast and Zileuton act on pathways involved in the inflammatory response, which is often exacerbated in IgE-mediated conditions. Antihistamines like Loratadine provide symptomatic relief from allergic reactions without directly influencing IgE levels. Additionally, natural compounds like Quercetin, Curcumin, and Epigallocatechin Gallate (EGCG) offer anti-inflammatory and antioxidant properties, which can modulate the immune system's response, potentially affecting IgE-related processes.