IFIT5 Activators
IFIT5, also known as Interferon-Induced Protein with Tetratricopeptide Repeats 5, plays a crucial role in antiviral response mechanisms, particularly in binding viral RNA lacking 2'-O methylation to inhibit replication. IFIT5 activators are a class of chemical compounds that enhance the functional activity of IFIT5, primarily through the modulation of pathways that are upstream of the protein or through direct interaction that promotes its stabilization, RNA binding ability, or interaction with other proteins involved in the antiviral response. For instance, certain nucleoside analogs that mimic the structure of RNA can bind to IFIT5, leading to a conformational change that enhances its ability to interact with non-2'-O-methylated RNA, a marker of viral RNA, thus viral replication. Moreover, small molecules that stabilize the expression of IFIT5 or its subcellular localization can also serve as activators by ensuring that IFIT5 is available in sufficient quantities and in the right cellular compartments to exert its effects.
In addition to these mechanisms, there are compounds that influence the phosphorylation state of proteins that interact with IFIT5, thereby modulating its activity. For example, kinase the phosphorylation of proteins that sequester IFIT5 can result in the liberation and subsequent activation of IFIT5, thereby enhancing its antiviral functions. Furthermore, specific signaling pathway modulators, such as those that activate the JAK-STAT pathway, can indirectly lead to the upregulation of IFIT5 as part of the interferon response. By increasing the overall antiviral state of the cell, these activators indirectly contribute to the heightened functional activity of IFIT5. Collectively, IFIT5 activators work through a variety of biochemical mechanisms, each converging on the enhancement of IFIT5's role in the innate immune response against viral pathogens.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, leading to an increase in intracellular cAMP levels. Elevated cAMP activates PKA, which can phosphorylate and thereby enhance the activity of IFIT5 as part of the antiviral response within cells. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol activates SIRT1, which is involved in the regulation of the innate immune response. SIRT1 can deacetylate and activate transcription factors that upregulate IFIT5 expression as a response to viral infection. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG inhibits certain kinases, altering signaling pathways that can lead to upregulation of IFIT5. EGCG can modulate the cellular stress response pathways, which are known to enhance the expression of IFIT5 during viral infection. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is known to activate PI3K/Akt signaling, which can lead to the transcriptional activation of IFIT5 as part of the cellular antiviral defense mechanism. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane activates Nrf2, leading to the expression of antioxidant response element (ARE)-driven genes, including IFIT5, as part of the oxidative stress response. | ||||||
Piperine | 94-62-2 | sc-205809 sc-205809A | 5 g 25 g | $37.00 $146.00 | 3 | |
Piperine can enhance the production of type I interferons, which in turn can increase the expression of IFIT5 as an interferon-stimulated gene involved in the innate immune response to viral infection. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Capsaicin activates TRPV1, which can lead to downstream signaling events that enhance the expression of IFIT5, contributing to the host cell's antiviral defenses. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits glycogen synthase kinase-3 (GSK-3). Inhibition of GSK-3 can lead to the activation of pathways that result in the upregulation of IFIT5 expression in response to viral stimuli. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate, a histone deacetylase inhibitor, can enhance the acetylation of histones near the IFIT5 gene, leading to its increased expression as part of the innate immune response. | ||||||
Indole-3-carbinol | 700-06-1 | sc-202662 sc-202662A sc-202662B sc-202662C sc-202662D | 1 g 5 g 100 g 250 g 1 kg | $39.00 $61.00 $146.00 $312.00 $1032.00 | 5 | |
Indole-3-Carbinol can modulate the aryl hydrocarbon receptor (AhR) pathway, which has been implicated in the transcriptional regulation of IFIT5 during the immune response to viral infection. | ||||||