IDS Activators
IDS Activators can be defined as a class of compounds that enhance the activity of the enzyme Iduronate 2-sulfatase (IDS). The chemicals in this class engage in a diverse set of interactions and mechanisms to influence IDS activity, often by modulating pathways and processes related to IDS function. The IDS enzyme plays a crucial role in the degradation of glycosaminoglycans (GAGs) within the lysosome. Therefore, compounds that influence GAG metabolism, lysosomal function, or related cellular processes may serve as indirect activators of IDS. For instance, Mannose-6-phosphate, N-acetyl-D-glucosamine, Glucosamine, and Chondroitin sulfate are all involved in GAG metabolism and could indirectly affect IDS activity by modulating the levels of its substrate. Ascorbic acid also influences GAG metabolism and could potentially affect IDS activity in the same manner.
Moreover, other activators like Manganese(II) chloride, Trehalose, Resveratrol, Quercetin, Tauroursodeoxycholic acid, Pyridoxal phosphate, and N-acetyl cysteine have diverse actions that can enhance cellular metabolism, lysosomal function, and stress responses. These compounds can indirectly influence IDS activity by creating an environment conducive to its function.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
D-Mannose | 3458-28-4 | sc-211180 sc-211180A | 100 g 250 g | $103.00 $161.00 | 1 | |
Mannose-6-phosphate is a key component in the targeting of lysosomal enzymes, including IDS. It can bind to the Mannose-6-phosphate receptor, facilitating the transport of the enzyme to the lysosome and potentially increasing its activity. | ||||||
N-Acetyl-D-glucosamine | 7512-17-6 | sc-286377 sc-286377B sc-286377A | 50 g 100 g 250 g | $94.00 $162.00 $306.00 | 1 | |
It is a precursor of hyaluronic acid and can modulate GAG metabolism. By influencing the substrate availability for IDS, it could indirectly impact IDS activity. | ||||||
D-Glucosamine | 3416-24-8 | sc-278917A sc-278917 | 1 g 10 g | $201.00 $779.00 | ||
Glucosamine is a precursor for glycosaminoglycans, and thus can potentially affect IDS activity by modulating the levels of its substrate. | ||||||
Chondroitin Sulfate, Bovine | 9007-28-7 | sc-203888 | 5 g | $94.00 | 1 | |
Chondroitin sulfate is a type of GAG that could potentially increase the activity of IDS by increasing substrate availability. | ||||||
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $46.00 | 5 | |
Ascorbic acid, or vitamin C, is required for the synthesis of collagen and certain neurotransmitters, and it can also influence the metabolism of GAGs, potentially affecting IDS activity. | ||||||
Manganese(II) chloride beads | 7773-01-5 | sc-252989 sc-252989A | 100 g 500 g | $19.00 $31.00 | ||
Manganese is a cofactor for many enzymes, and while it is not known to directly activate IDS, it could potentially enhance its activity by supporting the enzymatic machinery in the lysosome. | ||||||
D-(+)-Trehalose Anhydrous | 99-20-7 | sc-294151 sc-294151A sc-294151B | 1 g 25 g 100 g | $30.00 $167.00 $260.00 | 2 | |
Trehalose is a disaccharide that has been shown to enhance lysosomal function. This could indirectly increase the activity of IDS within the lysosome. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is known to upregulate various enzymes involved in metabolic pathways, and it might also stimulate IDS activity indirectly by enhancing cellular metabolism and lysosomal function. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is a flavonoid that can modulate multiple signaling pathways and may enhance lysosomal function, which could indirectly lead to increased IDS activity. | ||||||
Tauroursodeoxycholic Acid, Sodium Salt | 14605-22-2 | sc-281165 | 1 g | $644.00 | 5 | |
Tauroursodeoxycholic acid can improve cellular stress responses and contribute to enhanced lysosomal function, potentially influencing IDS activity. | ||||||