Id3 Activators

Id3, or Inhibitor of DNA binding 3, is a helix-loop-helix (HLH) protein that acts as a regulator of transcription. Encoded by the ID3 gene, this protein primarily functions by forming heterodimers with basic HLH transcription factors, subsequently inhibiting their DNA-binding ability and modulating gene expression. Id3 is vital in various cellular processes such as cell differentiation, proliferation, and apoptosis. It plays a critical role in tissue development, immune response, and cellular homeostasis. Given the broad range of biological functions modulated by Id3, there is significant interest in the chemical activators that can influence its expression and activity.

Chemical activators of Id3 can be categorized based on the distinct biochemical pathways they utilize to regulate this critical transcriptional modulator. For example, growth factors such as FGF2 and EGF activate specific receptors, triggering intracellular signaling cascades like MAPK/ERK that lead to Id3 upregulation.. Some compounds like PGE2 have an indirect influence on Id3.