ICA1L Inhibitors
Chemical inhibitors of ICA1L can effectively prevent the protein's activation by interfering with essential phosphorylation processes or kinase-mediated signaling pathways it relies upon. For instance, the PKC inhibitors Go6976, Ro-31-8220, Chelerythrine, BIM-I, and Ruboxistaurin block the phosphorylation of ICA1L by inhibiting the activity of PKC isoforms. Since phosphorylation by PKC is a prerequisite for ICA1L's functionality, the prevention of this modification by these inhibitors effectively diminishes the protein's activity. LY333531, another PKC inhibitor with a selective affinity for the PKCβ isoform, also contributes to the inhibition of ICA1L by specifically targeting the PKCβ-mediated phosphorylation sequence. This selectivity ensures that the phosphorylation events directly relevant to ICA1L's function are obstructed, leading to its functional inhibition.
Furthermore, the CaMKII inhibitors KN-93 and KN-62 prevent the CaMKII-dependent phosphorylation of ICA1L, a critical step necessary for its activation. By obstructing CaMKII, these inhibitors directly impede the activation pathway of ICA1L. Similarly, ML-7 and ML-9, inhibitors of MLCK, disrupt the cytoskeletal interactions essential for ICA1L's function by inhibiting the kinase responsible for modulating these interactions. K252a, a broad-spectrum protein kinase inhibitor, also plays a role in the inhibition of ICA1L by curtailing the activity of a range of kinases that would otherwise phosphorylate and activate ICA1L. Lastly, Triciribine targets the Akt pathway, which is connected to ICA1L activity. By inhibiting Akt, Triciribine blocks downstream phosphorylation events that are crucial for the functional activity of ICA1L, thereby serving as an effective means of inhibiting the protein.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Gö 6976 | 136194-77-9 | sc-221684 | 500 µg | $227.00 | 8 | |
Go6976 is a potent protein kinase C (PKC) inhibitor. Since ICA1L is a protein that requires phosphorylation for its activity, Go6976 inhibits ICA1L by preventing its phosphorylation by PKC isoforms. | ||||||
Ro 31-8220 | 138489-18-6 | sc-200619 sc-200619A | 1 mg 5 mg | $92.00 $245.00 | 17 | |
Ro-31-8220 is a broad-spectrum PKC inhibitor. ICA1L, being a substrate for PKC, is inhibited by Ro-31-8220 which inhibits the phosphorylation process necessary for ICA1L's activity. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $182.00 | 25 | |
KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII). ICA1L, which is a part of CaMKII-mediated signaling pathways, is inhibited by KN-93 through the blockade of CaMKII-dependent phosphorylation. | ||||||
KN-62 | 127191-97-3 | sc-3560 | 1 mg | $136.00 | 20 | |
KN-62 is another inhibitor of CaMKII. It inhibits ICA1L by blocking the CaMKII which is responsible for phosphorylating ICA1L, thus preventing its activation. | ||||||
Chelerythrine chloride | 3895-92-9 | sc-3547 sc-3547A | 5 mg 25 mg | $90.00 $317.00 | 17 | |
Chelerythrine is a selective inhibitor of PKC. It inhibits ICA1L by preventing its phosphorylation by PKC, which is essential for ICA1L function. | ||||||
LY-333,531 Hydrochloride | 169939-93-9 | sc-364215 sc-364215A | 1 mg 5 mg | $94.00 $287.00 | 6 | |
LY333531 is a selective inhibitor of PKCβ. By inhibiting PKCβ, LY333531 prevents the phosphorylation and subsequent activation of ICA1L. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $91.00 $267.00 | 13 | |
ML-7 is an inhibitor of myosin light chain kinase (MLCK). ICA1L, which interacts with cytoskeletal elements through MLCK, is functionally inhibited by ML-7 by blocking these interactions crucial for ICA1L activity. | ||||||
ML-9 | 105637-50-1 | sc-200519 sc-200519A sc-200519B sc-200519C | 10 mg 50 mg 100 mg 250 mg | $112.00 $449.00 $673.00 $1224.00 | 2 | |
ML-9 is also an inhibitor of MLCK. It functionally inhibits ICA1L by blocking the MLCK-mediated pathways that are essential for the cytoskeletal interactions of ICA1L. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $105.00 $242.00 | 36 | |
BIM-I is a selective PKC inhibitor. ICA1L activity, which relies on PKC-mediated phosphorylation, is inhibited by BIM-I through the blockade of PKC activity. | ||||||
K-252a | 99533-80-9 | sc-200517 sc-200517B sc-200517A | 100 µg 500 µg 1 mg | $129.00 $214.00 $498.00 | 19 | |
K252a is an indolocarbazole that is a potent inhibitor of protein kinases. ICA1L, which requires phosphorylation by various kinases for its activity, is inhibited by K252a through the blockade of these kinases. | ||||||