Date published: 2026-2-14

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HYPB Inhibitors

The chemical class referred to as HYPB inhibitors comprises a diverse group of compounds that have demonstrated the ability to modulate the activity of the Huntingtin Yeast Partner B (HYPB) protein. HYPB is associated with various cellular processes and has been implicated in the context of certain neurodegenerative conditions. These inhibitors interact with specific binding sites or functional domains within the HYPB protein, effectively altering its normal function. They often exert their inhibitory effects through mechanisms that interfere with HYPB's molecular interactions or disrupt its enzymatic activity. Structurally, HYPB inhibitors can vary widely, encompassing small organic molecules, peptides, and natural products. Their inhibitory potential may stem from their ability to competitively or allosterically hinder the normal interactions of HYPB with its native binding partners or substrates.

Researchers have identified and characterized these inhibitors using a combination of molecular biology techniques, biochemical assays, and computational modeling. Understanding the properties and mechanisms of HYPB inhibitors offers valuable insights into the complex molecular pathways involving HYPB and its roles within cellular processes, providing a foundation for potential future research endeavors.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Sodium phenylbutyrate

1716-12-7sc-200652
sc-200652A
sc-200652B
sc-200652C
sc-200652D
1 g
10 g
100 g
1 kg
10 kg
$77.00
$166.00
$622.00
$5004.00
$32783.00
43
(1)

This compound has been investigated for its potential to reduce mutant huntingtin aggregation and is thought to exert its effects partly through HYPB inhibition.

Sodium Butyrate

156-54-7sc-202341
sc-202341B
sc-202341A
sc-202341C
250 mg
5 g
25 g
500 g
$31.00
$47.00
$84.00
$222.00
19
(3)

Similar to sodium phenylbutyrate, sodium butyrate has been studied for its role in inhibiting HYPB and its potential therapeutic effects in Huntington's disease.

Cystamine dihydrochloride

56-17-7sc-217990
sc-217990A
25 g
100 g
$39.00
$105.00
(1)

Cystamine is a compound that has been explored for its potential to inhibit HYPB and modulate the progression of Huntington's disease.

Curcumin

458-37-7sc-200509
sc-200509A
sc-200509B
sc-200509C
sc-200509D
sc-200509F
sc-200509E
1 g
5 g
25 g
100 g
250 g
1 kg
2.5 kg
$37.00
$69.00
$109.00
$218.00
$239.00
$879.00
$1968.00
47
(1)

Curcumin, a natural compound found in turmeric, has exhibited HYPB inhibitory effects and has been studied for its neuroprotective properties in various neurodegenerative diseases, including Huntington's.

Coenzyme Q10

303-98-0sc-205262
sc-205262A
1 g
5 g
$71.00
$184.00
1
(1)

CoQ10 has been investigated for its potential to modulate HYPB activity and mitigate the effects of oxidative stress in Huntington's disease.

Lithium

7439-93-2sc-252954
50 g
$214.00
(0)

Lithium has been investigated for its ability to inhibit HYPB and its potential neuroprotective effects in Huntington's disease.