HSPC144 Inhibitors
HSPC144 inhibitors encompass a range of chemical compounds that interfere with various cellular processes and signaling pathways, which can indirectly lead to the inhibition of HSPC144 activity. For example, Cycloheximide, by halting protein synthesis, decreases the intracellular levels of HSPC144, thereby inhibiting its function. Similarly, proteasome inhibitors like MG132 may overload HSPC144 with aberrant proteins to refold, indirectly inhibiting its normal chaperone functions. eCompounds that inhibit other chaperones or components of the cellular protein quality control system can also indirectly affect the function of HSPC144. Inhibitors of heat shock proteins such as Hsp90, like 17-AAG or Geldanamycin, disrupt the chaperone network, potentially impairing HSPC144's function.
In addition to chaperone inhibitors, any disruption to the cell cycle and DNA repair mechanisms can indirectly influence HSPC144. For example, DNA damage response inhibitors like Camptothecin, which targets DNA topoisomerase I, might reduce the need for chaperone activity during cell cycle arrest, thereby affecting HSPC144's role in the cell.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
Inhibits protein biosynthesis by interfering with the translocation step in protein synthesis, thus preventing the elongation of the polypeptide chain. This would indirectly inhibit the function of HSPC144 by preventing its synthesis, leading to reduced levels of the protein in the cell. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
Proteasome inhibitor that prevents the degradation of ubiquitinated proteins. This can lead to the accumulation of misfolded or damaged proteins, potentially sequestering HSPC144 in efforts to refold these proteins and thereby reducing its availability for its other functional roles. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
A potent inhibitor of protein kinases which may indirectly inhibit HSPC144 by altering phosphorylation states of proteins within signaling pathways that HSPC144 is involved in, potentially altering its interaction with other proteins or its stability. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $70.00 $215.00 | 26 | |
Inhibits glycolysis by blocking glucose metabolism at the level of hexokinase, leading to energy depletion within the cell. This can indirectly inhibit HSPC144 function by reducing the ATP levels necessary for its proper activity, as chaperones like HSPC144 often require ATP to function. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
An mTOR inhibitor that can inhibit cell growth and proliferation. By inhibiting mTOR, the compound indirectly reduces protein synthesis, which could reduce the availability and function of HSPC144 as there would be fewer proteins for it to act upon, or reduced synthesis of HSPC144 itself. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Disrupts protein transport by inhibiting the exchange of proteins and other molecules between the Golgi apparatus and the endoplasmic reticulum. This could indirectly inhibit the function of HSPC144 by preventing its proper localization within the cell, which is necessary for its function. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Inhibits N-linked glycosylation, disrupting protein folding and increasing the unfolded protein response. This could lead to the sequestration of HSPC144 in an attempt to manage misfolded glycoproteins, reducing its availability for other functional activities. | ||||||
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $66.00 $101.00 $143.00 | 85 | |
Alkylates DNA and forms crosslinks, preventing DNA synthesis and cell division. This could indirectly inhibit the function of HSPC144 by reducing the overall rate of protein synthesis and thus the demand for its chaperone activity. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
A non-competitive inhibitor of the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) leading to depletion of endoplasmic reticulum Ca2+ stores and induction of the unfolded protein response. This can indirectly inhibit HSPC144 by increasing the cellular demand for chaperone activity and potentially overwhelming its capacity. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Antimalarial drug that raises the pH in intracellular organelles, inhibiting the degradation of proteins in lysosomes. This can lead to an accumulation of misfolded proteins, indirectly inhibiting the function of HSPC144 as it may be sequestered in refolding these proteins. | ||||||