HS3ST5 Inhibitors
Chemical inhibitors of HS3ST5 can function through various mechanisms to impede the enzyme's ability to transfer sulfate groups to its substrates. Chlorate is one such inhibitor that can obstruct HS3ST5 activity by oxidizing essential sulfhydryl groups within the enzyme's active site. This chemical alteration hampers the enzyme's function by disrupting the critical environment needed for the sulfation reaction. Similarly, Bisphenol A competes with the natural substrates of HS3ST5, binding to the active site and preventing the enzyme from catalyzing its typical biochemical reactions. This form of competitive inhibition is a common method by which molecules can decrease an enzyme's activity.
Other substances, such as Pentachlorophenol and Ellagic acid, also inhibit HS3ST5 but through a different approach. They bind to the enzyme's PAPS-binding site where the sulfate donor molecule typically attaches. By occupying this site, these inhibitors block the transfer of the sulfate group to the acceptor molecules, effectively stifling the enzyme's activity. Similarly, Quercetin interferes with HS3ST5 by adhering to the active site, preventing the normal enzymatic function. In contrast, 2,4-Dinitrochlorobenzene and Dibromosulphophthalein inhibit the enzyme by binding covalently to it, which blocks the active site and precludes the binding of the enzyme's natural substrates. Danazol, another chemical on the list, competes with substrates at the active site of HS3ST5, thus preventing the sulfonation of acceptor molecules. Lastly, Sodium molybdate targets the enzyme's molybdenum cofactor, a crucial component for the enzyme's function, thereby inhibiting the overall sulfonation activity of HS3ST5. These inhibitors, through their distinct mechanisms of action, all serve to impair the sulfotransferase activity of HS3ST5.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sodium chlorate | 7775-09-9 | sc-212938 | 100 g | $58.00 | 1 | |
Chlorate is an inhibitor of sulfotransferases, the enzyme family to which HS3ST5 belongs. It inhibits HS3ST5 by oxidizing the key sulfhydryl groups in the active site, which are essential for the transfer of sulfate groups from the donor molecule 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to the acceptor molecule, typically a glycosaminoglycan. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor that can increase the acetylation of histones, leading to a more open chromatin structure and potentially increased transcription of various genes. Its role in inhibiting HS3ST5 is indirect; by altering chromatin structure, it can influence the expression of enzymes and cofactors involved in the same pathway as HS3ST5 and thus inhibit its function. | ||||||
Bisphenol A | 80-05-7 | sc-391751 sc-391751A | 100 mg 10 g | $300.00 $490.00 | 5 | |
Bisphenol A can compete with the natural substrates of sulfotransferases like HS3ST5 for the sulfonation reaction. By binding to the active site of HS3ST5, it can inhibit the enzyme's function by preventing the proper substrate from binding, thus inhibiting the sulfonation process that HS3ST5 catalyzes. | ||||||
Pentachlorophenol | 87-86-5 | sc-257975 | 1 g | $32.00 | ||
Pentachlorophenol acts as an inhibitor of sulfotransferases by binding to the PAPS-binding site, which is the sulfate donor for the enzymatic reaction carried out by HS3ST5. By blocking this site, it inhibits the transfer of sulfate to the acceptor molecules, effectively inhibiting the function of HS3ST5. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin is a flavonoid that can inhibit a range of sulfotransferases. It inhibits HS3ST5 by binding to the enzyme's active site and preventing the transfer of the sulfate group from the donor molecule PAPS to the acceptor molecules. | ||||||
Ellagic Acid, Dihydrate | 476-66-4 | sc-202598 sc-202598A sc-202598B sc-202598C | 500 mg 5 g 25 g 100 g | $57.00 $93.00 $240.00 $713.00 | 8 | |
Ellagic acid is a polyphenol compound that inhibits sulfotransferases by binding to the PAPS binding site of the enzyme, thus preventing the essential sulfonation reaction carried out by HS3ST5. | ||||||
Danazol | 17230-88-5 | sc-203021 sc-203021A | 100 mg 250 mg | $90.00 $233.00 | 3 | |
Danazol is a synthetic steroid that inhibits sulfotransferases such as HS3ST5 by competing with the natural substrates for the active site, thereby preventing the enzyme from catalyzing the sulfonation of acceptor molecules. | ||||||
Sodium molybdate | 7631-95-0 | sc-236912 sc-236912A sc-236912B | 5 g 100 g 500 g | $55.00 $82.00 $316.00 | 1 | |
Sodium molybdate acts as an inhibitor of sulfotransferase enzymes, including HS3ST5. It inhibits enzymatic activity by interfering with the enzyme's molybdenum cofactor, which is essential for the transfer of sulfate groups from the donor molecule PAPS to the acceptor molecules | ||||||