Date published: 2025-12-5

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Homobifunctional Crosslinkers

Santa Cruz Biotechnology now offers a broad range of homobifunctional crosslinkers for use in various applications. Homobifunctional crosslinkers are chemical reagents that possess two identical reactive groups, enabling them to covalently link two similar functional groups within or between molecules. These crosslinkers are crucial in scientific research for studying protein-protein interactions, stabilizing protein structures, and creating multi-subunit complexes. Researchers utilize homobifunctional crosslinkers to investigate the spatial organization and dynamics of macromolecular assemblies, providing insights into the structural and functional relationships within biological systems. These crosslinkers are also employed in the development of biomaterials, where they enhance the mechanical properties and stability of synthetic polymers and hydrogels. In addition, homobifunctional crosslinkers play a significant role in immobilizing enzymes and other bioactive molecules onto solid supports, facilitating their use in biosensors, bioassays, and biocatalysis. By offering a comprehensive selection of high-quality homobifunctional crosslinkers, Santa Cruz Biotechnology supports advanced research in biochemistry, molecular biology, and materials science. These products enable scientists to achieve precise and reproducible results, driving innovations in the understanding of molecular interactions and the development of new biotechnological applications. View detailed information on our available homobifunctional crosslinkers by clicking on the product name.

Items 31 to 40 of 60 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

4,4′-Diisothiocyano-2,2′-dihydrostilbenedisulfonic Acid Disodium Salt

150321-88-3sc-281687
250 mg
$342.00
(0)

4,4'-Diisothiocyano-2,2'-dihydrostilbenedisulfonic Acid Disodium Salt is a homobifunctional compound featuring two isothiocyanate groups that engage in nucleophilic addition reactions. This compound exhibits remarkable stability and solubility in aqueous environments, allowing for efficient interaction with various nucleophiles. Its distinct reactivity enables the formation of cross-linked networks, promoting the development of innovative materials with enhanced mechanical and thermal properties.

4,4′-Diisothiocyanatostilbene-2,2′-disulfonic acid disodium salt

67483-13-0sc-214282
sc-214282B
sc-214282A
25 mg
250 mg
100 mg
$120.00
$260.00
$117.00
1
(2)

4,4'-Diisothiocyanatostilbene-2,2'-disulfonic acid disodium salt is a homobifunctional compound characterized by its dual isothiocyanate functionalities, which facilitate selective conjugation with amines and thiols. This compound demonstrates high reactivity and specificity in forming covalent bonds, leading to the creation of robust polymeric structures. Its unique sulfonic acid groups enhance solubility and ionic interactions, making it suitable for diverse chemical environments and applications.

3-Maleimidopropionic Acid Hydrazonium, Trifluoroacetate

359436-61-6sc-357610
25 mg
$320.00
(0)

3-Maleimidopropionic Acid Hydrazonium, Trifluoroacetate is a homobifunctional compound featuring maleimide groups that enable efficient thiol-reactive conjugation. Its hydrazonium component enhances nucleophilicity, promoting rapid reaction kinetics with electrophiles. The trifluoroacetate moiety contributes to its solubility in polar solvents, facilitating versatile interactions in various chemical systems. This compound's unique reactivity profile allows for the formation of stable linkages, making it a valuable tool in synthetic chemistry.

MTS-17-O5-MTS

384342-61-4sc-218886
25 mg
$360.00
(0)

MTS-17-O5-MTS is a homobifunctional compound characterized by its dual reactive sites that facilitate cross-linking through selective interactions. Its unique structure promotes rapid reaction kinetics, enabling efficient formation of covalent bonds with nucleophiles. The compound exhibits enhanced solubility in various solvents, allowing for diverse applications in chemical synthesis. Its distinct reactivity patterns make it an effective agent for creating stable molecular assemblies.

PEG NHS ester disulfide (n=7)

947601-98-1sc-236303
100 mg
$230.00
(1)

PEG NHS ester disulfide (n=7) is a homobifunctional reagent featuring two reactive NHS ester groups that enable efficient conjugation with amines. Its elongated PEG backbone enhances solubility and flexibility, promoting favorable steric interactions. The disulfide linkage provides a reversible bond, allowing for dynamic assembly and disassembly in various environments. This compound's unique reactivity and structural properties facilitate the formation of complex molecular networks.

1,10-Decadiyl Bismethanethiosulfonate

56-02-0sc-208713
25 mg
$360.00
(1)

1,10-Decadiyl Bismethanethiosulfonate is a homobifunctional compound characterized by its dual methanethiosulfonate groups, which enable selective thiol reactions. Its extended hydrocarbon chain enhances hydrophobic interactions, promoting stability in nonpolar environments. The compound exhibits unique reactivity, facilitating the formation of cross-linked structures through disulfide bond formation, which can influence reaction kinetics and molecular assembly in diverse chemical contexts.

α,α′-Paraxylyl Bismethanethiosulfonate

3948-46-7sc-220450
10 mg
$320.00
(0)

α,α'-Paraxylyl Bismethanethiosulfonate is a homobifunctional compound featuring two methanethiosulfonate moieties that engage in specific thiol-disulfide exchange reactions. Its para-substituted aromatic structure introduces steric hindrance, influencing the kinetics of reaction pathways. The compound's unique spatial arrangement allows for selective interactions with thiol groups, promoting the formation of stable cross-linked networks and enhancing its utility in various chemical synthesis applications.

Ethylene-bis-maleimide

5132-30-9sc-358228
100 mg
$224.00
(0)

Ethylene-bis-maleimide is a homobifunctional compound characterized by its two maleimide groups, which readily undergo Michael addition reactions with nucleophiles, particularly thiols. This reactivity facilitates the formation of covalent bonds, enabling the creation of robust polymeric networks. The compound's rigid structure and planar geometry enhance its ability to stabilize intermediates, influencing reaction kinetics and promoting selective cross-linking in diverse chemical environments.

1,11-Bismaleimidotetraethyleneglycol

86099-06-1sc-208715
25 mg
$330.00
(0)

1,11-Bismaleimidotetraethyleneglycol is a homobifunctional compound featuring two maleimide moieties that exhibit high reactivity towards nucleophiles, particularly amines and thiols. Its unique tetraethylene glycol backbone imparts flexibility, allowing for efficient spatial arrangement during cross-linking reactions. This flexibility, combined with the compound's ability to form stable covalent bonds, enhances its potential for creating tailored polymer architectures and influences the kinetics of polymerization processes.

O,O′-Bis[2-(N-Succinimidyl-succinylamino)ethyl]polyethylene glycol

186020-53-1sc-228867
1 g
$420.00
(0)

O,O'-Bis[2-(N-Succinimidyl-succinylamino)ethyl]polyethylene glycol is a homobifunctional reagent characterized by its dual succinimidyl groups, which facilitate selective conjugation with primary amines. The polyethylene glycol backbone provides hydrophilicity and steric hindrance, promoting solubility and reducing non-specific interactions. This compound's unique reactivity profile allows for controlled cross-linking, influencing the kinetics of conjugation and enabling the formation of complex biomolecular structures.