4,4prime-Diisothiocyanatostilbene-2,2prime-disulfonic acid disodium salt CAS: 207233-90-7
MF: C16H8N2Na2O6S4
MW: 498.47
A negatively charged homobifunctional cross-linking reagent and dye.

4,4′-Diisothiocyanatostilbene-2,2′-disulfonic acid disodium salt (CAS 207233-90-7)

4,4′-Diisothiocyanatostilbene-2,2′-disulfonic acid disodium salt | CAS 207233-90-7 is rated 5.0 out of 5 by 1.
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Alternate Names: DIDS; Disodium 4,4′-diisothiocyanatostilbene-2,2′-disulfonate
Application: 4,4′-Diisothiocyanatostilbene-2,2′-disulfonic acid disodium salt is a negatively charged homobifunctional cross-linking reagent and dye
CAS Number: 207233-90-7
Purity: ≥80%
Molecular Weight: 498.47
Molecular Formula: C16H8N2Na2O6S4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

4,4'-Diisothiocyanatostilbene-2,2'-disulfonic acid disodium salt hydrate is a reactive environment-sensitive dye for studying receptors and proteins. DIDS is a negatively charged homobifunctional cross-linking reagent, where the isothiocyanate groups react with primary amines at pH 9.0-10.0. It acts as a specific inhibitor of cellular anion permeability used in cell transport studies.


References

Okada, Y., et al., Volume-sensitive chloride channels involved in apoptotic volume decrease and cell death. J. Membr. Biol. 209, 21-29, (2006); :Pusch, M., et al., Channel or transporter? The CLC saga continues. Exp. Physiol. 91, 149-152, (2006); :Alper, S.L., Molecular physiology of SLC4 anion exchangers. Exp. Physiol. 91, 153-161, (2006); :Hua, S., and Inesi, G., Lys515-Lys492 cross-linking by DIDS interferes with substrate utilization by the sarcoplasmic reticulum ATPase. Biophys. J. 73, 2149-2155, (1997); :Kavanaugh, M.P., et al., Affinity labeling of hemoglobin with 4,4'-diisothiocyanostilbene-2,2'-disulfonate: covalent cross-linking in the 2,3-diphosphoglycerate binding site. Biochemistry 27, 1804-1808, (1988);

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in potassium bicarbonate
Storage :
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
5702690
SMILES :
C1=CC(=C(C=C1N=C=S)S(=O)(=O)[O-])/C=C/C2=C(C=C(C=C2)N=C=S)S(=O)(=O)[O-].[Na+].[Na+]

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Various publications cite the use of 4 Various publications cite the use of 4,4'-Diisothiocyanatostilbene-2,2'-disulfonic acid disodium salt hydrate, a reactive environment-sensitive dye, for studying receptors and proteins. It also acts as a specific inhibitor of cellular anion permeability used in cell transport studies. -SCBT Publication Review
Date published: 2015-04-19
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