Molecular structure of 4,4′-Diisothiocyanatostilbene-2,2′-disulfonic acid disodium salt, CAS Number: 67483-13-0
4,4′-Diisothiocyanatostilbene-2,2′-disulfonic acid disodium salt (CAS 67483-13-0)
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Alternate Names:
DIDS; Disodium 4,4′-diisothiocyanatostilbene-2,2′-disulfonate
Application:
4,4′-Diisothiocyanatostilbene-2,2′-disulfonic acid disodium salt is a negatively charged homobifunctional cross-linking reagent and dye
CAS Number:
67483-13-0
Purity:
≥80%
Molecular Weight:
498.47
Molecular Formula:
C16H8N2Na2O6S4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
4,4′-Diisothiocyanatostilbene-2,2′-disulfonic acid disodium salt hydrate is a reactive environment-sensitive dye for studying receptors and proteins. DIDS is a negatively charged homobifunctional cross-linking reagent, where the isothiocyanate groups react with primary amines at pH 9.0-10.0. It acts as a specific inhibitor of cellular anion permeability used in cell transport studies.
4,4′-Diisothiocyanatostilbene-2,2′-disulfonic acid disodium salt (CAS 67483-13-0) References
- A novel role of 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid as an activator of the phosphatase activity catalyzed by plasma membrane Ca2+-ATPase. | Santos, FT., et al. 1999. Biochemistry. 38: 10552-8. PMID: 10441152
- Effects of barium, furosemide, ouabaine and 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS) on ionophoretically-induced changes in extracellular potassium concentration in hippocampal slices from rats and from patients with epilepsy. | Jauch, R., et al. 2002. Brain Res. 925: 18-27. PMID: 11755897
- Reversible inhibition by 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid of the plasma membrane (Ca(2+)+Mg2+)ATPase from kidney proximal tubules. | Guilherme, A., et al. 1991. Biochemistry. 30: 5700-6. PMID: 1828368
- Chloride channel blocker 4,4-diisothiocyanatostilbene-2,2'-disulfonic acid inhibits nitric oxide-induced apoptosis in cultured rat hippocampal neurons. | Yin, J., et al. 2013. Neural Regen Res. 8: 121-6. PMID: 25206481
- DIDS (4,4'-Diisothiocyanatostilbene-2,2'-disulfonate) directly inhibits caspase activity in HeLa cell lysates. | Benítez-Rangel, E., et al. 2015. Cell Death Discov. 1: 15037. PMID: 27551467
- 4,4'-Diisothiocyanatostilbene-2,2'-disulfonic acid attenuates spontaneous recurrent seizures and vasogenic edema following lithium-pilocarpine induced status epilepticus. | Yang, T., et al. 2017. Neurosci Lett. 653: 51-57. PMID: 28501694
- The Interaction between Trolox and 4,4'-diisothiocyanatostilbene-2,2'-disulfonic Acid on Hypoxic Pulmonary Vasoconstriction in the Isolated Rabbit Lung. | Mansoori, S., et al. 2017. Iran J Med Sci. 42: 284-291. PMID: 28533577
- 4,4'-Diisothiocyanatostilbene-2,2'-disulfonic acid inhibits CD3-T cell antigen receptor-stimulated Ca2+ influx in human T lymphocytes. | Rosoff, PM., et al. 1988. J Biol Chem. 263: 19535-40. PMID: 2974037
- 4,4'-Diisothiocyanatostilbene-2,2'-disulfonate modulates voltage-gated K+ current and influences cell cycle arrest in androgen sensitive and insensitive human prostate cancer cell lines. | George, K., et al. 2020. Toxicol Mech Methods. 30: 358-369. PMID: 32193973
- Ca(2+)-dependent permeabilization of the inner mitochondrial membrane by 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS). | Bernardes, CF., et al. 1994. Biochim Biophys Acta. 1188: 93-100. PMID: 7947908
- Inhibition of succinic dehydrogenase and F0F1-ATP synthase by 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS). | Bernardes, CF., et al. 1997. Z Naturforsch C J Biosci. 52: 799-806. PMID: 9463937
- Inhibition of sodium current by chloride channel blocker 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS) in guinea pig cardiac ventricular cells. | Liu, J., et al. 1998. J Cardiovasc Pharmacol. 31: 558-67. PMID: 9554805
- DIDS (4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid) increases iodide trapping, inhibits thyroperoxidase and antagonizes the TSH-induced apical iodide efflux in porcine thyroid cells. | Amphoux-Fazekas, T., et al. 1998. Mol Cell Endocrinol. 141: 129-40. PMID: 9723894
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
4,4′-Diisothiocyanatostilbene-2,2′-disulfonic acid disodium salt, 25 mg | sc-214282 | 25 mg | $120.00 | |||
4,4′-Diisothiocyanatostilbene-2,2′-disulfonic acid disodium salt, 100 mg | sc-214282A | 100 mg | $117.00 | |||
4,4′-Diisothiocyanatostilbene-2,2′-disulfonic acid disodium salt, 250 mg | sc-214282B | 250 mg | $260.00 |