4,4'-Diisothiocyanatostilbene-2,2'-disulfonic acid disodium salt hydrate is a reactive environment-sensitive dye for studying receptors and proteins. DIDS is a negatively charged homobifunctional cross-linking reagent, where the isothiocyanate groups react with primary amines at pH 9.0-10.0. It acts as a specific inhibitor of cellular anion permeability used in cell transport studies.
Okada, Y., et al., Volume-sensitive chloride channels involved in apoptotic volume decrease and cell death. J. Membr. Biol. 209, 21-29, (2006); :Pusch, M., et al., Channel or transporter? The CLC saga continues. Exp. Physiol. 91, 149-152, (2006); :Alper, S.L., Molecular physiology of SLC4 anion exchangers. Exp. Physiol. 91, 153-161, (2006); :Hua, S., and Inesi, G., Lys515-Lys492 cross-linking by DIDS interferes with substrate utilization by the sarcoplasmic reticulum ATPase. Biophys. J. 73, 2149-2155, (1997); :Kavanaugh, M.P., et al., Affinity labeling of hemoglobin with 4,4'-diisothiocyanostilbene-2,2'-disulfonate: covalent cross-linking in the 2,3-diphosphoglycerate binding site. Biochemistry 27, 1804-1808, (1988);
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