Histone Modification
Items 41 to 50 of 101 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
TAK-960 | 1137868-52-0 | sc-364631 sc-364631A | 5 mg 10 mg | $310.00 $653.00 | 1 | |
TAK-960 is a potent histone modification agent that selectively targets the HDAC6 enzyme, disrupting its deacetylation activity. This interference results in elevated acetylation of histones, promoting a more open chromatin structure. Its unique binding affinity facilitates specific interactions with the enzyme, influencing downstream signaling pathways and altering gene expression dynamics. The compound exhibits distinct kinetic properties, enhancing its efficacy in modulating histone acetylation states. | ||||||
GSK J1 | 1373422-53-7 | sc-391113 sc-391113A | 10 mg 50 mg | $189.00 $797.00 | ||
GSK J1 is a selective inhibitor of the histone demethylase KDM6A, which plays a crucial role in regulating histone methylation. By binding to the active site of KDM6A, GSK J1 stabilizes the methylated state of histones, leading to a compact chromatin configuration. This compound exhibits unique interaction dynamics that modulate the enzymatic activity, influencing epigenetic landscapes and cellular processes. Its distinct reaction kinetics enhance the specificity of histone modification. | ||||||
Histone Lysine Methyltransferase Inhibitor Inhibitor | 935693-62-2 (free base) | sc-202651 | 5 mg | $148.00 | 4 | |
Histone Lysine Methyltransferase Inhibitor targets specific lysine residues on histones, disrupting the methylation process essential for chromatin remodeling. By competitively binding to the enzyme's active site, it alters the conformational dynamics of the methyltransferase, thereby affecting substrate recognition and catalytic efficiency. This inhibition leads to altered gene expression patterns, showcasing its role in fine-tuning epigenetic regulation through unique molecular interactions. | ||||||
GSK J4 | sc-391114 sc-391114A | 10 mg 50 mg | $215.00 $860.00 | 5 | ||
GSK J4 functions as a selective inhibitor of histone demethylases, particularly targeting the Jumonji C (JmjC) domain-containing enzymes. By forming stable interactions with the active site, it effectively disrupts the demethylation of histone lysine residues. This interference not only stabilizes methylated histones but also influences chromatin structure and accessibility, thereby modulating transcriptional activity. Its unique binding affinity highlights its potential to reshape epigenetic landscapes through specific molecular engagements. | ||||||
PKA substrate | sc-3059 | 0.5 mg | $95.00 | 1 | ||
PKA substrate acts as a pivotal modulator in histone modification by serving as a phosphorylation target for protein kinase A. Upon phosphorylation, it induces conformational changes in histone proteins, enhancing their interaction with transcription factors and chromatin remodeling complexes. This process alters the local chromatin architecture, facilitating or inhibiting gene expression. The substrate's specificity for serine and threonine residues underscores its role in fine-tuning epigenetic regulation through dynamic signaling pathways. | ||||||
Romidepsin | 128517-07-7 | sc-364603 sc-364603A | 1 mg 5 mg | $214.00 $622.00 | 1 | |
Romidepsin functions as a potent inhibitor of histone deacetylases (HDACs), leading to an accumulation of acetylated histones. This modification disrupts the compact structure of chromatin, promoting a more open configuration that enhances transcriptional accessibility. By selectively targeting HDACs, Romidepsin influences the balance of acetylation and deacetylation, thereby modulating gene expression patterns and impacting cellular processes through intricate epigenetic mechanisms. | ||||||
Chidamide | 743420-02-2 | sc-364462 sc-364462A sc-364462B | 1 mg 5 mg 25 mg | $61.00 $245.00 $1173.00 | ||
Chidamide acts as a selective inhibitor of histone deacetylases (HDACs), facilitating the accumulation of acetylated histones within the chromatin. This alteration in histone modification leads to a more relaxed chromatin structure, enhancing the accessibility of transcription factors to DNA. By specifically engaging with certain HDAC isoforms, Chidamide fine-tunes the epigenetic landscape, influencing gene regulation and cellular dynamics through complex molecular interactions. | ||||||
AMI-1, free acid | 134-47-4 | sc-300192 | 1 g | $96.00 | ||
AMI-1, free acid, functions as a potent modulator of histone methylation, specifically targeting histone methyltransferases. By disrupting the interaction between these enzymes and their substrates, it alters the methylation status of histones, leading to significant changes in chromatin architecture. This modification promotes a more compact chromatin state, thereby influencing transcriptional repression and gene silencing through intricate biochemical pathways and feedback mechanisms. | ||||||
Butein | 487-52-5 | sc-202510 sc-202510A | 5 mg 50 mg | $172.00 $306.00 | 8 | |
Butein acts as a selective inhibitor of histone deacetylases, influencing histone acetylation dynamics. By binding to the active sites of these enzymes, it enhances the acetylation of histones, resulting in a more relaxed chromatin structure. This alteration facilitates transcriptional activation and gene expression through the modulation of chromatin accessibility. Its unique interaction with specific histone marks underscores its role in epigenetic regulation and cellular signaling pathways. | ||||||
Tenovin-1 | 380315-80-0 | sc-222342 | 10 mg | $87.00 | 1 | |
Tenovin-1 is a potent modulator of histone acetylation, functioning primarily as an inhibitor of sirtuins, a class of histone deacetylases. By disrupting the deacetylation process, it promotes an accumulation of acetylated histones, leading to chromatin remodeling. This shift in histone modification alters the recruitment of transcription factors and co-regulators, thereby influencing gene expression patterns. Its selective action on specific sirtuin isoforms highlights its nuanced role in epigenetic regulation. | ||||||