Histone H3 Inhibitors
Histone H3 inhibitors belong to a class of compounds that have garnered significant interest in the realm of molecular biology and biochemistry due to their pivotal role in modulating chromatin structure and gene expression. Histone H3, a core component of the nucleosome, plays a crucial role in packaging and organizing DNA within the nucleus of eukaryotic cells. The post-translational modifications of specific amino acid residues on the histone tail, including lysine and arginine residues of Histone H3, have been shown to regulate chromatin accessibility and thus impact gene expression patterns. Histone H3 inhibitors, as the name suggests, are compounds designed to interfere with the modification patterns on these histones, thereby influencing the chromatin landscape.
These inhibitors are designed to target the enzymes responsible for adding or removing various chemical groups, such as acetyl, methyl, and phosphate groups, to specific amino acids on the histone tails. By inhibiting these enzymes, histone H3 inhibitors can perturb the finely tuned equilibrium of histone modifications, leading to altered chromatin conformation and affecting gene transcription. The diverse chemical structures of these inhibitors allow researchers to fine-tune their specificity for particular enzymes or histone modification sites, offering a powerful tool for investigating the intricate relationship between chromatin structure and gene regulation. In conclusion, histone H3 inhibitors represent a compelling class of compounds that have opened up new avenues of research in the field of molecular biology. By selectively disrupting the histone modification patterns on Histone H3, these inhibitors enable scientists to decipher the complex mechanisms underlying chromatin remodeling and gene expression control.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Vorinostat is a histone deacetylase (HDAC) inhibitor that targets class I and II HDAC enzymes, leading to increased histone acetylation. This disrupts chromatin structure, promoting transcription and potentially influencing gene expression related to cell cycle regulation and apoptosis. | ||||||
Romidepsin | 128517-07-7 | sc-364603 sc-364603A | 1 mg 5 mg | $218.00 $634.00 | 1 | |
Romidepsin is a cyclic peptide HDAC inhibitor primarily targeting class I HDACs. It binds to the catalytic domain of HDACs, preventing deacetylation of histones. This results in altered chromatin structure and gene expression patterns, potentially impacting cell differentiation and apoptosis. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is a natural product HDAC inhibitor that affects class I and II HDACs. By inhibiting deacetylation, it increases histone acetylation levels, leading to modified chromatin structure and gene expression changes associated with cell cycle control and cellular differentiation. | ||||||
ITF2357 | 732302-99-7 | sc-364513 sc-364513A | 5 mg 50 mg | $340.00 $1950.00 | ||
Givinostat is an HDAC inhibitor targeting class I and II HDACs. It modulates histone acetylation, potentially impacting gene expression linked to inflammation, cell cycle progression, and immune response regulation. | ||||||
Belinostat | 414864-00-9 | sc-269851 sc-269851A | 10 mg 100 mg | $156.00 $572.00 | ||
Belinostat inhibits class I, II, and IV HDACs, leading to increased histone acetylation. This may affect gene expression related to cell cycle regulation, apoptosis, and immune responses. | ||||||
Panobinostat | 404950-80-7 | sc-208148 | 10 mg | $200.00 | 9 | |
Panobinostat is a pan-HDAC inhibitor that targets class I, II, and IV HDACs. It interferes with histone deacetylation, potentially altering gene expression linked to cell growth, differentiation, and apoptosis. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $90.00 $212.00 | 24 | |
Entinostat selectively inhibits class I HDACs, leading to increased histone acetylation. This may influence gene expression related to cell cycle control, apoptosis, and immune system modulation. | ||||||
Scriptaid | 287383-59-9 | sc-202807 sc-202807A | 1 mg 5 mg | $64.00 $183.00 | 11 | |
Scriptaid is an HDAC inhibitor that enhances histone acetylation by targeting class I and II HDACs. This could impact gene expression patterns associated with cell proliferation, differentiation, and apoptosis. | ||||||
Tubastatin A | 1252003-15-8 | sc-507298 | 10 mg | $114.00 | ||
Tubastatin A is a selective HDAC6 inhibitor. By inhibiting HDAC6, it regulates the acetylation of non-histone proteins, potentially affecting cell motility, autophagy, and other cellular processes. | ||||||
PCI-24781 | 783355-60-2 | sc-364565 sc-364565A | 5 mg 50 mg | $186.00 $1357.00 | 1 | |
PCI-24781 is an HDAC inhibitor targeting class I and II HDACs. Its action on histone acetylation may influence gene expression linked to cell cycle progression, apoptosis, and DNA repair mechanisms. | ||||||