Histone cluster 1 H3I Inhibitors
Histone cluster 1 H3I Inhibitors constitute a specialized category of chemical compounds meticulously designed to selectively inhibit the activity of histone cluster 1, with a specific emphasis on the H3I subtype. Histones play a fundamental role in organizing DNA within the nucleus, forming nucleosomes that serve as the structural foundation for chromatin. The H3I designation refers to a variant of histone H3, one of the core histones essential for nucleosome assembly. As a specific variant within histone cluster 1, H3I becomes a focal point for researchers seeking to unravel the intricacies of chromatin dynamics and gene regulation.
The development of Histone cluster 1 H3I Inhibitors demands a thorough understanding of the structural characteristics of histone H3I and its specific role within chromatin organization. These inhibitors are intricately crafted for specificity, aiming to selectively bind to key regions of Histone cluster 1 H3I and disrupt its normal functions. By employing these inhibitors in experimental contexts, researchers can explore the consequences of inhibiting this particular histone variant, providing valuable insights into chromatin remodeling and the intricate regulation of gene expression. The study of histones, including variants like H3I, significantly contributes to advancing our understanding of epigenetic mechanisms, offering crucial insights into the dynamic processes governing gene regulation and the complex orchestration of cellular functions at the chromatin level.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
Decitabine is a hypomethylating agent that can incorporate into DNA and inhibit DNA methyltransferase, leading to DNA demethylation and the potential alteration of gene expression, including histone genes. | ||||||
Panobinostat | 404950-80-7 | sc-208148 | 10 mg | $200.00 | 9 | |
Panobinostat is a potent histone deacetylase inhibitor that may alter the acetylation status of histones, affecting the expression of various genes, potentially including those of histone proteins. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Vorinostat, also known as SAHA, is a histone deacetylase inhibitor that can lead to hyperacetylation of histones, impacting gene expression patterns, possibly including histone cluster genes. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate acts as a histone deacetylase inhibitor, which can alter gene expression through changes in chromatin structure and function, potentially affecting histone gene regulation. | ||||||
Mocetinostat | 726169-73-9 | sc-364539 sc-364539B sc-364539A | 5 mg 10 mg 50 mg | $214.00 $247.00 $1463.00 | 2 | |
Mocetinostat is a histone deacetylase inhibitor that can modify the acetylation state of histones, influencing gene transcription, including that of histone encoding genes. | ||||||
Romidepsin | 128517-07-7 | sc-364603 sc-364603A | 1 mg 5 mg | $218.00 $634.00 | 1 | |
Romidepsin is a cyclic peptide that inhibits histone deacetylase, affecting chromatin structure and potentially downregulating the transcription of various genes, including histone genes. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor known to affect chromatin structure and gene expression, which may include the transcriptional regulation of histone genes. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Valproic acid has histone deacetylase inhibitory activity and can influence gene expression by changing the acetylation state of histones, which could include effects on histone gene expression. | ||||||
Sirtinol | 410536-97-9 | sc-205976 sc-205976A | 1 mg 5 mg | $38.00 $113.00 | 14 | |
Sirtinol targets sirtuin histone deacetylases, which might lead to altered histone acetylation and deacetylation dynamics, potentially influencing the expression of histone genes. | ||||||