H2-Kk Activators
H2-Kk, also known as Histocompatibility 2, K region, locus K, is a gene and protein that plays a pivotal role in the immune system of mice. It is part of the major histocompatibility complex (MHC) class I family of genes, which are responsible for presenting antigens (peptides) from intracellular pathogens or abnormal proteins to cytotoxic T cells. H2-Kk specifically serves this function in mice.
The H2-Kk gene encodes a cell surface glycoprotein known as MHC class I molecule H-2Kk, which is expressed on the surface of various cells, including immune cells and other nucleated cells throughout the body. This glycoprotein serves as a key component of the immune system's surveillance mechanism. It binds to antigens from viruses, bacteria, or other pathogens, as well as aberrant proteins from within the cell, and presents them on the cell surface. This presentation allows cytotoxic T cells to recognize and eliminate infected or abnormal cells, contributing to the body's defense against infections and cancers.H2-Kk is highly polymorphic, meaning that there are multiple genetic variants (alleles) of this gene within the mouse population. This polymorphism enables the immune system to recognize a wide range of antigens and ensures immune diversity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lipopolysaccharide, E. coli O55:B5 | 93572-42-0 | sc-221855 sc-221855A sc-221855B sc-221855C | 10 mg 25 mg 100 mg 500 mg | $98.00 $171.00 $425.00 $1560.00 | 12 | |
LPS, a component of the outer membrane of gram-negative bacteria, can upregulate MHC class I molecules by triggering innate immune responses. | ||||||
Polyinosinic-polycytidylic acid potassium salt | 31852-29-6 | sc-202767 | 5 mg | $198.00 | ||
Poly(I:C), a synthetic analog of double-stranded RNA, may stimulate H2-Kk expression by mimicking viral infection and activating immune pathways. | ||||||
Imiquimod | 99011-02-6 | sc-200385 sc-200385A | 100 mg 500 mg | $67.00 $284.00 | 6 | |
Imiquimod, a Toll-like receptor 7 agonist, potentially enhances H2-Kk expression by stimulating type I interferon production. | ||||||
Levamisole Hydrochloride | 16595-80-5 | sc-205730 sc-205730A | 5 g 10 g | $43.00 $68.00 | 18 | |
Levamisole, an immunomodulator, may increase H2-Kk expression through its effects on the immune system, although the exact mechanism is unclear. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Vitamin D3 may influence H2-Kk expression indirectly through its immunomodulatory effects, impacting antigen presentation. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
PGE2, an inflammatory mediator, might modulate H2-Kk expression by influencing cytokine production and immune cell activity. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
Azacytidine, a nucleoside analog, may affect H2-Kk expression through epigenetic modulation, altering gene expression. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium Butyrate, a short-chain fatty acid, could influence H2-Kk expression via histone deacetylase inhibition, affecting chromatin structure and gene expression. | ||||||