Gucy2d Inhibitors
Gucy2d inhibitors constitute a specific class of chemical compounds designed to modulate the activity of the Guanylate cyclase 2D (Gucy2d) enzyme. Guanylate cyclases are a family of enzymes that play crucial roles in signal transduction and cellular processes by catalyzing the conversion of guanosine triphosphate (GTP) into cyclic guanosine monophosphate (cGMP), a critical secondary messenger molecule in various physiological pathways. Gucy2d, a member of this enzyme family, is expressed in specific tissues and cells within the human body. The primary objective of Gucy2d inhibitors is to interact with the Gucy2d enzyme, potentially influencing its catalytic activity and, subsequently, impacting downstream cellular events mediated by cGMP.
Typically, Gucy2d inhibitors are composed of small molecules or chemical compounds specifically designed to bind to the active site or allosteric sites of the Gucy2d enzyme. This interaction can lead to the modulation of Gucy2d's behavior, potentially affecting its ability to catalyze the conversion of GTP to cGMP. Researchers are primarily interested in unraveling the physiological roles and signaling pathways associated with Gucy2d, as well as understanding how inhibiting its activity with these compounds may shed light on various cellular processes. The development of Gucy2d inhibitors represents an active area of research within the field of molecular pharmacology and biochemistry, contributing to our understanding of cellular signaling mechanisms and the functions of guanylate cyclases in cellular physiology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid, derived from vitamin A, is involved in the regulation of gene expression. It may inhibit Gucy2d expression by altering retinoid-related signaling pathways, which are known to be important in visual system development. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone, a glucocorticoid, can regulate gene expression by activating glucocorticoid receptors. It may inhibit Gucy2d indirectly by influencing transcription factors involved in its regulation. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
Triptolide is a compound shown to inhibit the transcription of a wide range of genes. It could reduce Gucy2d expression by interfering with general transcription machinery. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Actinomycin D binds to DNA and inhibits transcription elongation by RNA polymerase, which could decrease the expression of Gucy2d by preventing mRNA synthesis. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits mTOR, a kinase that is part of the signaling pathway involved in protein synthesis. By doing so, it could downregulate the translation of Gucy2d mRNA into the protein. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $269.00 $1050.00 | 26 | |
Alpha-amanitin is a potent inhibitor of RNA polymerase II, the enzyme responsible for mRNA synthesis in eukaryotes. Inhibition by alpha-amanitin could result in decreased Gucy2d expression. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $43.00 $189.00 $316.00 $663.00 | 6 | |
DRB is an adenosine analogue that inhibits RNA polymerase II, potentially reducing Gucy2d expression by halting mRNA elongation. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
Cycloheximide inhibits eukaryotic protein synthesis by interfering with the translocation step in protein elongation. This could result in the decreased expression of Gucy2d protein. | ||||||
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $66.00 $101.00 $143.00 | 85 | |
Mitomycin C forms DNA adducts, leading to cross-linking and inhibition of DNA synthesis and transcription. This can reduce Gucy2d expression by preventing gene transcription. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
Camptothecin inhibits DNA topoisomerase I, causing DNA damage and potentially downregulating Gucy2d expression as a cellular response to DNA damage. | ||||||