GSTM3 Inhibitors
Inhibitors of GSTM3, as a chemical class, would consist of molecules that either compete with the enzyme's substrates, directly interact with the active site, or modify the enzyme's functionality through allosteric effects. These inhibitors could affect the detoxification and metabolism processes mediated by GSTM3.
The activity of GSTM3 can be modulated through various mechanisms by these compounds. Ethacrynic acid and acetaminophen can affect GSTM3 activity by altering the availability of glutathione, the substrate for conjugation reactions. Sulfasalazine and bromosulfophthalein may inhibit GSTM3 by directly interacting with the active site of the enzyme, preventing substrate binding. Compounds like ellagic acid and curcumin can modulate enzyme activity potentially by binding to the enzyme and influencing its expression or by direct inhibition. Chloroacetamide and naphthalene-2,3-dicarboxaldehyde may inhibit the enzyme by covalently modifying cysteine residues critical for the catalytic activity of GSTM3.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ethacrynic acid | 58-54-8 | sc-257424 sc-257424A | 1 g 5 g | $90.00 $300.00 | 5 | |
A diuretic that can inhibit GSTs by conjugating with glutathione, potentially reducing GSTM3 activity by depleting its substrate. | ||||||
Sulfasalazine | 599-79-1 | sc-204312 sc-204312A sc-204312B sc-204312C | 1 g 2.5 g 5 g 10 g | $61.00 $77.00 $128.00 $209.00 | 8 | |
A compound that has been shown to inhibit various GSTs and may affect GSTM3 by binding to its active site. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
A natural phenolic compound found in turmeric that has been reported to inhibit GST activity and may interact with GSTM3. | ||||||
meso-Tetra(p-hydroxyphenyl)porphine | 51094-17-8 | sc-263466 sc-263466A | 250 mg 1 g | $88.00 $260.00 | ||
A photosensitizer used in photodynamic therapy that has been shown to inhibit GSTs, which could affect GSTM3 as well. | ||||||
2,4,6-Tri-tert-butylphenol | 732-26-3 | sc-231022 | 100 g | $80.00 | ||
A fluorogenic aldehyde used to label proteins that may inhibit GSTs by forming covalent adducts with nucleophilic residues in the active site. | ||||||
Vitamin K3 | 58-27-5 | sc-205990B sc-205990 sc-205990A sc-205990C sc-205990D | 5 g 10 g 25 g 100 g 500 g | $26.00 $36.00 $47.00 $136.00 $455.00 | 3 | |
A vitamin K derivative that can act as a substrate for GSTs but at high concentrations can inhibit their activity, possibly affecting GSTM3. | ||||||
Fentin acetate | 900-95-8 | sc-235133 | 250 mg | $79.00 | ||
An organotin compound that has been shown to inhibit GSTs, potentially affecting GSTM3 by binding to the active site. | ||||||
Acetaminophen | 103-90-2 | sc-203425 sc-203425A sc-203425B | 5 g 100 g 500 g | $41.00 $61.00 $194.00 | 11 | |
A common analgesic that in excessive doses can deplete glutathione levels, thereby potentially inhibiting GSTM3 by reducing its substrate availability. | ||||||