GSTM3 Activators
The chemicals listed above can potentially activate GSTM3 or influencethe related signaling pathways. Resveratrol, found in grapes and berries, increases the expression and activity of GSTM3 by promoting its binding to substrates and enhancing detoxification processes. Curcumin, found in turmeric, upregulates GSTM3 expression and enzymatic activity by acting as an antioxidant and activating Nrf2. Sulforaphane, present in cruciferous vegetables, indirectly activates GSTM3 by modulating the Nrf2 pathway and promoting its nuclear translocation.
Epigallocatechin-3-gallate (EGCG), a major polyphenol in green tea, activates GSTM3 by increasing its expression and promoting its interaction with substrates. Quercetin, a flavonoid in fruits and vegetables, upregulates GSTM3 expression and enhances its enzymatic activity by facilitating the conjugation of glutathione to xenobiotics. Caffeic acid, found in coffee and plants, increases GSTM3 expression and activity by enhancing substrate binding and protecting against oxidative stress. Indole-3-carbinol, present in cruciferous vegetables, indirectly activates GSTM3 by modulating the AhR pathway and increasing its detoxification activity. Lycopene, a pigment in tomatoes, activates GSTM3 by increasing its expression and facilitating substrate binding. Genistein, found in soy products, upregulates GSTM3 expression and enhances its enzymatic activity by promoting glutathione conjugation to xenobiotics. Allyl isothiocyanate, present in cruciferous vegetables, indirectly activates GSTM3 by modulating the Nrf2 pathway and increasing its detoxification function. Ellagic acid, found in fruits and nuts, upregulates GSTM3 expression and promotes substrate binding for detoxification. Diallyl disulfide, present in garlic, increases GSTM3 expression and activity by promoting substrate binding and protecting against oxidative damage.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol is a natural polyphenolic compound found in various plants, such as grapes and berries. It has been shown to activate GSTM3 by increasing its expression and enzymatic activity. Resveratrol promotes the binding of GSTM3 to its substrates, leading to enhanced detoxification processes. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane, found in cruciferous vegetables like broccoli and cabbage, can indirectly activate GSTM3 by modulating the Nrf2 signaling pathway. It induces Nrf2 nuclear translocation, leading to the upregulation of GSTM3 expression and subsequent enhancement of its enzymatic activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG, a major polyphenol in green tea, has been shown to activate GSTM3 by increasing its expression and enzymatic activity. EGCG can directly bind to GSTM3, promoting its interaction with substrates and facilitating detoxification processes. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin, a flavonoid abundant in various fruits and vegetables, can activate GSTM3 by upregulating its expression and enhancing its enzymatic activity. Quercetin interacts with GSTM3, promoting the conjugation of glutathione to xenobiotics and facilitating their elimination. | ||||||
Caffeic Acid | 331-39-5 | sc-200499 sc-200499A | 1 g 5 g | $31.00 $61.00 | 1 | |
Caffeic acid, a phenolic compound found in coffee and other plant sources, can activate GSTM3 by increasing its expression and enzymatic activity. Caffeic acid enhances the binding of GSTM3 to its substrates, facilitating the detoxification of various xenobiotics and protecting against oxidative stress. | ||||||
Indole-3-carbinol | 700-06-1 | sc-202662 sc-202662A sc-202662B sc-202662C sc-202662D | 1 g 5 g 100 g 250 g 1 kg | $38.00 $60.00 $143.00 $306.00 $1012.00 | 5 | |
Indole-3-carbinol, present in cruciferous vegetables, can indirectly activate GSTM3 by modulating the aryl hydrocarbon receptor (AhR) signaling pathway. It activates AhR, leading to the upregulation of GSTM3 expression and subsequent enhancement of its detoxification activity. | ||||||
Lycopene | 502-65-8 | sc-205738 sc-205738A sc-205738B | 1 mg 5 mg 1 g | $143.00 $571.00 $6125.00 | 4 | |
Lycopene, a carotenoid pigment found in tomatoes and other fruits, can activate GSTM3 by increasing its expression and promoting its enzymatic activity. Lycopene facilitates the binding of GSTM3 to its substrates, enhancing the detoxification processes mediated by this protein. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein, an isoflavone found in soy products, can activate GSTM3 by upregulating its expression and enhancing its enzymatic activity. Genistein increases the binding affinity of GSTM3 to xenobiotics, facilitating their glutathione conjugation and subsequent detoxification. | ||||||
Allyl isothiocyanate | 57-06-7 | sc-252361 sc-252361A sc-252361B | 5 g 100 g 500 g | $43.00 $66.00 $117.00 | 3 | |
Allyl isothiocyanate, a compound present in cruciferous vegetables like mustard and horseradish, can indirectly activate GSTM3 by modulating the Nrf2 signaling pathway. It promotes Nrf2 nuclear translocation, leading to increased GSTM3 expression and subsequent enhancement of its detoxification function. | ||||||
Ellagic Acid, Dihydrate | 476-66-4 | sc-202598 sc-202598A sc-202598B sc-202598C | 500 mg 5 g 25 g 100 g | $57.00 $93.00 $240.00 $713.00 | 8 | |
Ellagic acid, a polyphenol found in various fruits and nuts, can activate GSTM3 by upregulating its expression and promoting its enzymatic activity. Ellagic acid enhances the binding of GSTM3 to xenobiotics, facilitating their detoxification and protecting against oxidative stress. | ||||||