GST Inhibitors

Glutathione S-transferases (GSTs) are a family of enzymes that play a crucial role in cellular defense mechanisms by facilitating the conjugation of the antioxidant molecule glutathione with a wide range of hydrophobic and electrophilic compounds, including toxins, drugs, and reactive oxygen species. This process serves to neutralize and eliminate harmful substances from the body, protecting cells from oxidative stress and maintaining cellular homeostasis. GSTs are involved in various cellular pathways, including drug metabolism, xenobiotic detoxification, and protection against oxidative damage. Their importance extends beyond detoxification, as some GSTs are also involved in signal transduction and regulation of apoptosis.Glutathione S-transferase inhibitors target the enzymatic activity of GSTs, aiming to disrupt their role in detoxification and other cellular processes. These inhibitors can act either directly by binding to the active site of GSTs or indirectly by affecting their gene expression and activity levels.