Date published: 2025-9-12

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GSE1 Activators

GSE1 activators are compounds that modulate various signaling pathways or cellular conditions, potentially influencing the activity of GSE1 indirectly. These chemicals operate through mechanisms such as activation of kinases like PKC and PKA, alterations in cAMP levels, and changes in intracellular calcium dynamics, each of which could subsequently affect the phosphorylation status or conformation of GSE1 or its interacting partners. For instance, agents like PMA and Forskolin activate kinases that could phosphorylate GSE1 or its associated binding proteins, leading to functional changes in GSE1's activity.

Similarly, ionophores and calcium-modulating agents such as Ionomycin and A-23187 elevate intracellular calcium levels, which could activate or modulate a range of calmodulin-dependent processes, potentially influencing GSE1. The role of GSE1 in cellular signaling and its potential regulation by phosphorylation suggest that compounds which inhibit protein phosphatases, such as Okadaic Acid and Calyculin A, may lead to an enhanced phosphorylation state of GSE1, thereby affecting its function. Moreover, other activators that increase the levels of secondary messengers within cells, like 8-Br-cAMP, db-cAMP, and Isoproterenol, act on GSE1 indirectly by modulating kinase signaling pathways. Stress pathway modulators like Anisomycin activate SAPKs, potentially altering GSE1's role in the stress response. Lastly, nitric oxide donors like Spermine NONOate can influence cellular signaling through S-nitrosylation, which could affect GSE1 or its associated partners.

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Spermine NONOate

136587-13-8sc-202816
sc-202816A
5 mg
25 mg
$52.00
$192.00
5
(1)

Releases NO and can lead to the activation of soluble guanylyl cyclase, possibly affecting GSE1 through protein S-nitrosylation.