Date published: 2026-4-13

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GRK 2 Antibodies

Santa Cruz Biotechnology delivers a wide array of GRK 2 monoclonal antibodies for research focused on understanding G protein-coupled receptor signaling. GRK 2 Antibodies are validated for multiple applications, including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA).G protein-coupled receptor kinase 2 (GRK 2) plays a crucial role in the regulation of G protein-coupled receptors (GPCRs), which are vital for numerous physiological processes. By phosphorylating activated GPCRs, GRK 2 facilitates their desensitization and internalization, thereby modulating cellular responses to external signals. Understanding GRK 2 function is essential for elucidating the mechanisms underlying various diseases, including heart failure and cancer. Research has shown that GRK 2 expression levels can significantly impact cellular signaling pathways and therapeutic responses. Recent studies have highlighted the importance of GRK 2 in immune cell function and inflammation. Investigating GRK 2 continues to reveal new insights into cellular communication and disease progression. Santa Cruz Biotechnology monoclonal antibodies enable researchers worldwide to advance scientific understanding of GRK 2's role in health and disease.

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GRK 2 Antibodies

Empty Table HeaderProduct NameCATALOG #ISOTYPEEPITOPEAPPLICATIONSSpeciesCitationsRATING

GRK 2 Antibody (C-9)

sc-13143mouse IgG2a κ468-689 (h)WB, IP, IF, ELISAm, r, h
58
(14)

GRK 2 Antibody (F-9)

sc-166284mouse IgG1 κ661-699 (h)WB, IP, IF, ELISAm, r, h
2
(6)

GRK 2 Antibody (E-7)

sc-166283mouse IgG2b κ661-689 (h)WB, IP, IF, ELISAm, r, h

new

(1)

GRK 2 Antibody (G-12)

sc-271359mouse IgG2a κ661-699 (h)WB, IP, IF, IHC(P), ELISAm, r, h

new

(2)

GRK 2 CRISPR Knockout, HDR and Double Nickase Plasmids

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

GRK 2 CRISPR/Cas9 KO Plasmid (h)

sc-400558hGene KnockoutGFP0
(0)

GRK 2 HDR Plasmid (h)

sc-400558-HDRhHomology Directed RepairPuromycin0
(0)

GRK 2 Double Nickase Plasmid (h)

sc-400558-NIChGene KnockoutPuromycin0
(0)

GRK 2 Double Nickase Plasmid (h2)

sc-400558-NIC-2hGene KnockoutPuromycin0
(0)

GRK 2 CRISPR/Cas9 KO Plasmid (m)

sc-431016mGene KnockoutGFP0
(0)

GRK 2 HDR Plasmid (m)

sc-431016-HDRmHomology Directed RepairPuromycin0
(0)

GRK 2 Double Nickase Plasmid (m)

sc-431016-NICmGene KnockoutPuromycin0
(0)

GRK 2 Double Nickase Plasmid (m2)

sc-431016-NIC-2mGene KnockoutPuromycin0
(0)

GRK 2 CRISPR Activation Products

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

GRK 2 CRISPR Activation Plasmid (h)

sc-400558-ACThGene ActivationPuro, Blast, Hygro0
(0)

GRK 2 siRNA, shRNA Plasmid and shRNA Lentiviral Particle Gene Silencers

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

GRK 2 siRNA (h)

sc-29337hGene SilencingN/A
13
(0)

GRK 2 shRNA Plasmid (h)

sc-29337-SHhGene SilencingPuromycin
13
(0)

GRK 2 shRNA (h) Lentiviral Particles

sc-29337-VhGene SilencingPuromycin
13
(0)

GRK 2 siRNA (m)

sc-35513mGene SilencingN/A
2
(0)

GRK 2 shRNA Plasmid (m)

sc-35513-SHmGene SilencingPuromycin
2
(0)

GRK 2 shRNA (m) Lentiviral Particles

sc-35513-VmGene SilencingPuromycin
2
(0)

GRK 2 siRNA (r)

sc-270408rGene SilencingN/A0
(0)

GRK 2 shRNA Plasmid (r)

sc-270408-SHrGene SilencingPuromycin0
(0)

GRK 2 shRNA (r) Lentiviral Particles

sc-270408-VrGene SilencingPuromycin0
(0)