GRHPR Activators
GRHPR activators primarily influence the glyoxylate and dicarboxylate metabolism pathways, where GRHPR plays a crucial role. Pyruvate, L-Lactate, Alanine, Oxaloacetate, and Acetyl-CoA, by increasing the pool of hydroxypyruvate, indirectly enhance the activity of GRHPR. These compounds contribute to an increased availability of GRHPR's substrate, leading to enhanced enzymatic activity. Pyruvate, formed from various metabolic processes, serves as a central hub in this enhancement. It provides hydroxypyruvate, which GRHPR then converts to D-glycerate. This increased substrate availability directly influences GRHPR's functional role in the cell.
On the other hand, compounds like Glycolate, Glutamate, NADH, NADPH, Succinate, Aspartate, and Serine work through different but interconnected metabolic pathways. Glycolate, for instance, enhances GRHPR activity by providing an alternative substrate pathway. NADH and NADPH, as cofactors, directly augment the enzymatic efficiency of GRHPR. Their increased levels boost GRHPR's ability to reduce its specific substrates. Similarly, the metabolism of amino acids such as Glutamate, Aspartate, and Serine contributes to the pool of hydroxypyruvate. This not only ensures a steady supply of substrate for GRHPR's action but also maintains its functional significance in the metabolic network.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
L-Alanine | 56-41-7 | sc-396825 sc-396825A sc-396825B sc-396825C | 1 g 100 g 500 g 1 kg | $32.00 $102.00 $439.00 $755.00 | ||
Alanine, through transamination reactions, forms pyruvate. This increase in pyruvate concentration can indirectly enhance GRHPR activity by providing more hydroxypyruvate, a substrate for GRHPR, thus promoting its functional activity. | ||||||
Oxaloacetic Acid | 328-42-7 | sc-279934 sc-279934A sc-279934B | 25 g 100 g 1 kg | $306.00 $963.00 $7980.00 | 1 | |
Oxaloacetate is a key intermediate in the TCA cycle and can influence GRHPR activity. It can increase the levels of pyruvate through anaplerotic reactions, indirectly enhancing GRHPR's function in metabolizing hydroxypyruvate. | ||||||
Glyoxylic acid monohydrate | 563-96-2 | sc-250065 sc-250065A | 10 g 25 g | $27.00 $37.00 | ||
Glycolate, a substrate in glyoxylate metabolism, can enhance GRHPR activity by providing an alternative substrate pathway. Its conversion to glyoxylate, which GRHPR can then reduce to glycolate, enhances the protein's functional role in this metabolic process. | ||||||
L-Glutamic Acid | 56-86-0 | sc-394004 sc-394004A | 10 g 100 g | $297.00 $577.00 | ||
Glutamate, through its involvement in amino acid metabolism, can indirectly enhance GRHPR activity. Its conversion to alpha-ketoglutarate and subsequent metabolic transformations can increase pyruvate levels, indirectly influencing GRHPR activity. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $57.00 $191.00 $302.00 $450.00 $1800.00 $3570.00 $10710.00 | 4 | |
NADH, as a cofactor, is directly involved in the enzymatic activity of GRHPR. An increased availability of NADH can enhance GRHPR's reductive activity on glyoxylate and hydroxypyruvate, thereby promoting its functional role. | ||||||
β-Nicotinamide adenine dinucleotide phosphate | 53-59-8 | sc-215560 sc-215560A | 100 mg 250 mg | $182.00 $319.00 | ||
NADPH, another crucial cofactor for GRHPR, can enhance its enzymatic activity. An increase in NADPH levels can directly augment GRHPR's ability to reduce glyoxylate and hydroxypyruvate, enhancing its functional activity in metabolic pathways. | ||||||
Acetyl coenzyme A trisodium salt | 102029-73-2 | sc-210745 sc-210745A sc-210745B | 1 mg 5 mg 1 g | $47.00 $92.00 $5826.00 | 3 | |
Acetyl-CoA, through its involvement in metabolic pathways, can indirectly influence GRHPR activity. It can increase pyruvate levels by participating in various metabolic reactions, which in turn can enhance GRHPR's functional activity. | ||||||
Succinic acid | 110-15-6 | sc-212961B sc-212961 sc-212961A | 25 g 500 g 1 kg | $45.00 $75.00 $133.00 | ||
Succinate, a component of the TCA cycle, can indirectly influence GRHPR activity. Its conversion to fumarate and then to malate, and eventually to pyruvate, can enhance the availability of hydroxypyruvate, thus indirectly enhancing GRHPR activity. | ||||||
L-Aspartic acid | 56-84-8 | sc-472377A sc-472377 sc-472377B | 25 g 100 g 500 g | $40.00 $33.00 $48.00 | ||
Aspartate can contribute to increasing pyruvate levels through transamination reactions. This increase in pyruvate can enhance the availability of hydroxypyruvate, indirectly increasing GRHPR activity in its specific metabolic role. | ||||||
L-Serine | 56-45-1 | sc-397670 sc-397670A sc-397670B sc-397670C sc-397670D | 1 g 100 g 1 kg 5 kg 10 kg | $20.00 $133.00 $546.00 $1224.00 $2040.00 | ||
Serine, through its metabolism, can increase the pool of hydroxypyruvate, a substrate for GRHPR. This enhancement of substrate availability can indirectly increase GRHPR activity by providing more substrate for its enzymatic action. | ||||||