Granulocytee Marker Activators
Granulocyte markers are a set of proteins that are characteristically expressed on the surface or within granulocytes, which are a pivotal subset of white blood cells playing a crucial role in the innate immune response. These markers are essential for the identification, differentiation, and functional analysis of granulocyte populations. The expression of granulocyte markers is a highly regulated process that can be influenced by various chemical compounds, which can either upregulate or induce the expression of these proteins. Understanding the molecular pathways through which these markers are expressed is essential for advancing our knowledge of immune system functioning and the cellular mechanisms at play during the immune response.
Researchers have identified several non-peptidic chemical compounds that can serve as activators to increase the expression of granulocyte markers. Vitamin D3, for instance, is known to enhance the transcription of target genes involved in immune function, including those associated with granulocytes, by activating the vitamin D receptor pathway. Retinoic acid, another such compound, interacts with retinoic acid receptors to stimulate the transcriptional activation of genes during granulocyte differentiation. Lipopolysaccharide (LPS), a component of the outer membrane of gram-negative bacteria, can upregulate granulocyte marker expression through toll-like receptor 4 signaling, which is crucial for the innate immune response to bacterial pathogens. Additionally, compounds like sodium butyrate, which acts as a histone deacetylase inhibitor, can lead to increased histone acetylation and promote gene expression. Each of these compounds interacts with specific cellular pathways to initiate a cascade of reactions that ultimately lead to the upregulation of granulocyte marker proteins, shedding light on the complex regulatory networks that govern immune cell function.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Cholecalciferol, through its hormonal action, can upregulate the expression of "Granulocyte Marker" by activating vitamin D receptors, which in turn enhance the transcription of target genes in granulocytes. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid can stimulate the upregulation of "Granulocyte Marker" expression by binding to retinoic acid receptors, which are involved in the transcriptional activation of genes during myeloid cell differentiation. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
By inhibiting glycogen synthase kinase-3, lithium chloride can stimulate the Wnt signaling pathway, leading to the upregulation of "Granulocyte Marker" as part of the hematopoietic process. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate, as a histone deacetylase inhibitor, can increase histone acetylation, thereby promoting the transcriptional activation of "Granulocyte Marker" genes within granulocytes. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone can stimulate the expression of "Granulocyte Marker" by activating glucocorticoid receptors, leading to anti-inflammatory responses and the transcription of immune-related genes. | ||||||
Lipopolysaccharide, E. coli O55:B5 | 93572-42-0 | sc-221855 sc-221855A sc-221855B sc-221855C | 10 mg 25 mg 100 mg 500 mg | $98.00 $171.00 $425.00 $1560.00 | 12 | |
LPS can dramatically upregulate "Granulocyte Marker" expression through toll-like receptor 4 signaling, which plays a pivotal role in the innate immune response to bacterial infection. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol can upregulate "Granulocyte Marker" by activating sirtuin pathways, leading to the transcriptional activation of genes associated with longevity and inflammatory response in immune cells. | ||||||
Arsenic(III) oxide | 1327-53-3 | sc-210837 sc-210837A | 250 g 1 kg | $89.00 $228.00 | ||
Arsenic trioxide can upregulate "Granulocyte Marker" during the differentiation of promyelocytes into mature granulocytes by altering transcription factor activity and promoting apoptosis of leukemic cells. | ||||||
Zymosan | 9010-72-4 | sc-296863 sc-296863A | 100 mg 1 g | $99.00 $599.00 | 1 | |
Zymosan stimulates an immune response by engaging pattern-recognition receptors, inducing the expression of "Granulocyte Marker" in the context of fungal recognition and clearance. | ||||||
1α,25-Dihydroxyvitamin D3 | 32222-06-3 | sc-202877B sc-202877A sc-202877C sc-202877D sc-202877 | 50 µg 1 mg 5 mg 10 mg 100 µg | $220.00 $645.00 $1000.00 $1500.00 $440.00 | 32 | |
This metabolically active form of vitamin D3 can enhance the expression of "Granulocyte Marker" by binding to its nuclear receptor and promoting the transcription of genes involved in calcium homeostasis and immune function. | ||||||