GRAF Activators
GRAF activators constitute a distinct chemical class of compounds recognized for their unique role in modulating the activity of GRAF, or GTPase Regulator Associated with Focal Adhesion Kinase. GRAF, also known as Oligophrenin-1-like protein (OPHN1L), is a signaling protein involved in various cellular processes, including cytoskeletal rearrangement and membrane trafficking. GRAF activators are designed to selectively target and enhance the function of GRAF, which plays a crucial role in regulating membrane dynamics and endocytosis through its Rho GTPase-activating protein (RhoGAP) domain.
At the molecular level, the mechanism of GRAF activation is intricate and involves interactions with specific protein domains and post-translational modifications. GRAF activators are pivotal in dissecting the precise signaling pathways and molecular networks in which GRAF participates. These compounds offer valuable tools for researchers studying intracellular trafficking, actin dynamics, and cellular morphology, as they enable the manipulation of GRAF's function to explore its downstream effects on cellular processes. Furthermore, understanding GRAF activators contributes to our broader knowledge of cellular signaling and the intricate ways in which cells regulate their structural and functional characteristics, ultimately influencing their behavior and responses to external stimuli.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
A 83-01 | 909910-43-6 | sc-203791 sc-203791A | 10 mg 50 mg | $202.00 $811.00 | 16 | |
A regulator of various cellular processes; might influence GRAF expression during epithelial-to-mesenchymal transition (EMT). | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Increases cAMP levels and could influence GRAF expression via PKA-mediated signaling pathways. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Affects differentiation and might influence GRAF expression in specific cellular contexts. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
With its diverse effects on cellular signaling, curcumin might have an indirect influence on GRAF expression. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
By targeting Rho signaling, these inhibitors might have a downstream effect on GRAF expression. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $70.00 $215.00 | 26 | |
Impacts cellular metabolism and might influence GRAF expression under metabolic stress. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
As an mTOR inhibitor, rapamycin could have indirect effects on GRAF expression in the context of cell migration and growth. | ||||||
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $183.00 $313.00 $464.00 $942.00 $1723.00 | 7 | |
An inhibitor of non-muscle myosin II, it might influence GRAF expression during cell motility processes. | ||||||
Simvastatin | 79902-63-9 | sc-200829 sc-200829A sc-200829B sc-200829C | 50 mg 250 mg 1 g 5 g | $31.00 $89.00 $135.00 $443.00 | 13 | |
A statin known to influence Rho/Rac signaling, it might indirectly affect GRAF expression. | ||||||