GPR83 Activators

G Protein-Coupled Receptor 83 (GPR83) is a protein in humans that is encoded by the GPR83 gene. This protein is part of the large family of G protein-coupled receptors (GPCRs), which are involved in translating signals from outside the cell into intracellular responses.GPCRs function by binding to specific molecules or ligands outside the cell, triggering a conformational change in the receptor and initiating a series of intracellular events. These events often involve the activation of G proteins, leading to various cellular responses.In the immune system, GPR83 is largely expressed in T cells, indicating a role in immune function. Its expression is upregulated in regulatory T cells, which are critical for maintaining immune tolerance and blocking autoimmunity.

In the central nervous system, GPR83 is abundantly expressed in the hypothalamus, a region involved in regulating many body functions including energy homeostasis and circadian rhythms. Some studies suggest GPR83 might be involved in controlling energy balance and food intake, but the underlying mechanisms remain unclear.Regarding disease associations, altered GPR83 signaling has been implicated in several disorders, including autoimmune diseases and obesity. However, these potential links require further research for validation.