GPR40 Activators
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
GW 9508 | 885101-89-3 | sc-203069 | 10 mg | $125.00 | ||
GW 9508 is a potent agonist of GPR40, characterized by its ability to engage in hydrophobic interactions with specific residues in the receptor's transmembrane domains. This binding stabilizes the receptor in an active conformation, promoting enhanced signaling through the phospholipase C pathway. The compound's unique steric properties facilitate a rapid onset of action, influencing receptor dynamics and potentially modulating downstream metabolic processes. Its selectivity underscores its role in fine-tuning cellular responses. | ||||||
TUG-424 | 1082058-99-8 | sc-222379 sc-222379A | 5 mg 25 mg | $278.00 $909.00 | ||
TUG-424 acts as a selective agonist for GPR40, exhibiting unique binding characteristics that enhance receptor activation. Its molecular structure allows for specific hydrogen bonding with key amino acids, promoting a conformational shift that amplifies intracellular signaling cascades. The compound's kinetic profile indicates a swift interaction with the receptor, leading to a pronounced effect on lipid metabolism. Additionally, TUG-424's distinct hydrophobic regions contribute to its receptor affinity and specificity. | ||||||
4-Hydroxy-isophthalic acid dimethyl ester | 5985-24-0 | sc-336445 | 1 g | $144.00 | ||
4-Hydroxy-isophthalic acid dimethyl ester serves as a potent GPR40 modulator, characterized by its ability to engage in specific hydrophobic and electrostatic interactions with the receptor. This compound facilitates a unique allosteric modulation, enhancing receptor sensitivity to endogenous ligands. Its structural features promote efficient receptor dimerization, influencing downstream signaling pathways. The compound's rapid binding kinetics and favorable solubility profile further optimize its interaction dynamics with GPR40. | ||||||
Linoleic Acid | 60-33-3 | sc-200788 sc-200788A sc-200788B sc-200788C | 100 mg 1 g 5 g 25 g | $33.00 $63.00 $163.00 $275.00 | 4 | |
As a polyunsaturated fatty acid, linoleic acid can activate GPR40, potentially boosting its expression. | ||||||
Docosa-4Z,7Z,10Z,13Z,16Z,19Z-hexaenoic Acid (22:6, n-3) | 6217-54-5 | sc-200768 sc-200768A sc-200768B sc-200768C sc-200768D | 100 mg 1 g 10 g 50 g 100 g | $92.00 $206.00 $1744.00 $7864.00 $16330.00 | 11 | |
DHA is an omega-3 fatty acid that may act on GPR40 to induce its expression and affect insulin secretion. | ||||||
α-Linolenic Acid | 463-40-1 | sc-205545 sc-205545A | 50 mg 250 mg | $37.00 $113.00 | 2 | |
This plant-based omega-3 fatty acid can modulate GPR40 expression by acting as an endogenous ligand. | ||||||
Oleic Acid | 112-80-1 | sc-200797C sc-200797 sc-200797A sc-200797B | 1 g 10 g 100 g 250 g | $36.00 $102.00 $569.00 $1173.00 | 10 | |
Oleic acid, a monounsaturated fat, could increase GPR40 expression due to its role as a natural agonist. | ||||||
Palmitic Acid | 57-10-3 | sc-203175 sc-203175A | 25 g 100 g | $112.00 $280.00 | 2 | |
Palmitic acid is a saturated fatty acid that may influence GPR40 expression through its agonistic activity. | ||||||
MEDICA 16 | 87272-20-6 | sc-203131 sc-203131A | 5 mg 10 mg | $188.00 $260.00 | 1 | |
Medica 16 is a synthetic ligand for GPR40 that may increase its expression, influencing insulin dynamics. | ||||||