GPR39 Inhibitors
GPR39 Inhibitors primarily operate by blocking the signalling pathways that GPR39 is directly involved in. This can be achieved by inhibiting the Gq/11 proteins, as GPR39 signals through these proteins. Specific inhibitors for these proteins include YM-254890, FR 900359, and UBO-QIC. By inhibiting the Gq/11 proteins, these chemical compounds can lead to the functional inhibition of GPR39. In addition, the inhibition of downstream components of the Gq/11 proteins, such as PI3K and MEK, can also induce the functional inhibition of GPR39. This inhibition can be achieved with compounds like LY294002, Wortmannin, PD98059, and U0126.
In addition to the Gq/11 pathway, GPR39 can also signal through the G12/13 proteins. Therefore, the inhibition of these proteins and their downstream components can also result in the functional inhibition of GPR39. M119 is a specific G12/13 inhibitor, while Y-27632 is a ROCK inhibitor, a downstream component of the G12/13 proteins. Finally, GPR39 inhibitors also include compounds like ICI 182,780, GW 9662, and ZD 1839, which act by inhibiting the estrogen receptor, PPARγ, and EGFR, respectively.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
YM 254890 | 568580-02-9 | sc-507356 | 1 mg | $500.00 | ||
YM-254890 is a Gq/11 inhibitor. GPR39 signals through Gq/11 proteins, so inhibiting these proteins can result in the functional inhibition of GPR39. | ||||||
FR 900359 | 107530-18-7 | sc-507357 | 500 µg | $222.00 | ||
UBO-QIC is a Gq/11 inhibitor. The inhibition of Gq/11 proteins, which are required for GPR39 to signal, can lead to the functional inhibition of GPR39. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is a ROCK inhibitor. ROCK is downstream of G12/13, and since GPR39 can signal through G12/13 proteins, inhibiting ROCK can indirectly lead to the functional inhibition of GPR39. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor. PI3K is downstream of Gq/11, and since GPR39 signals through Gq/11 proteins, inhibiting PI3K can indirectly lead to the functional inhibition of GPR39. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is another PI3K inhibitor. It can indirectly lead to the functional inhibition of GPR39 by inhibiting PI3K, which is downstream of Gq/11 that GPR39 signals through. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a MEK inhibitor. MEK is downstream of Gq/11, and since GPR39 signals through Gq/11 proteins, inhibiting MEK can indirectly lead to the functional inhibition of GPR39. | ||||||
ICI 182,780 | 129453-61-8 | sc-203435 sc-203435A | 1 mg 10 mg | $81.00 $183.00 | 34 | |
ICI 182,780 is an estrogen receptor antagonist. Since estrogen can enhance GPR39 signaling, inhibiting estrogen receptors can indirectly lead to the functional inhibition of GPR39. | ||||||
GW 9662 | 22978-25-2 | sc-202641 | 5 mg | $68.00 | 30 | |
GW 9662 is a PPARγ inhibitor. Since PPARγ can enhance GPR39 signaling, inhibiting PPARγ can indirectly lead to the functional inhibition of GPR39. | ||||||
2-Chloroadenine | 1839-18-5 | sc-220719 | 1 g | $300.00 | ||
ZD 1839 is an EGFR inhibitor. Since EGFR can enhance GPR39 signaling, inhibiting EGFR can indirectly lead to the functional inhibition of GPR39. | ||||||