Gpr165 Inhibitors
GPR165 inhibitors belong to a specific category of chemical compounds designed to target and modulate the activity of the G-protein coupled receptor 165 (GPR165). G-protein coupled receptors (GPCRs) are a large family of cell surface receptors that play crucial roles in various physiological processes by transducing extracellular signals into intracellular responses. GPR165, one of the members of the GPCR family, is a protein that is expressed in certain tissues and cells within the human body. The role of GPR165 in cellular signaling and its potential involvement in various biological pathways make it an attractive target for drug discovery and chemical intervention.
GPR165 inhibitors are small molecules or compounds designed to specifically interact with GPR165 and modulate its activity. These inhibitors are developed to bind to the receptor's active site or allosteric sites, effectively blocking or altering the receptor's function. By doing so, GPR165 inhibitors can potentially influence downstream signaling pathways and cellular responses associated with this receptor, which may have implications for various physiological processes. Researchers are primarily interested in understanding the physiological and pathological roles of GPR165 and how inhibiting its activity can impact cellular functions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylyl cyclase, increasing cAMP levels, which may downregulate Gpr165 expression through cAMP responsive element binding. | ||||||
Yohimbine hydrochloride | 65-19-0 | sc-204412 sc-204412A sc-204412B | 1 g 5 g 25 g | $50.00 $168.00 $520.00 | 2 | |
Yohimbine acts as an alpha-2 adrenergic receptor antagonist, altering noradrenergic signaling, which can modulate the expression of related GPCRs. | ||||||
Propranolol | 525-66-6 | sc-507425 | 100 mg | $180.00 | ||
Propranolol is a beta-adrenergic receptor antagonist and could impact the expression levels of related GPCRs through feedback mechanisms. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD 98059 is an MEK inhibitor, which may suppress ERK pathway signaling, potentially influencing Gpr165 expression linked to this pathway. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB 203580 is a p38 MAPK inhibitor, which could modulate stress-related signaling pathways affecting Gpr165 expression. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY 294002 is a PI3K inhibitor, which may alter AKT signaling and impact Gpr165 expression through downstream effects on transcription factors. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR signaling, potentially affecting the translation of proteins, including Gpr165, by influencing mRNA translation processes. | ||||||
Chelerythrine | 34316-15-9 | sc-507380 | 100 mg | $540.00 | ||
Chelerythrine is a potent inhibitor of protein kinase C, which may affect Gpr165 expression by modulating PKC-dependent signaling pathways. | ||||||
W-7 | 61714-27-0 | sc-201501 sc-201501A sc-201501B | 50 mg 100 mg 1 g | $163.00 $300.00 $1642.00 | 18 | |
W-7 is a calmodulin antagonist, which may influence intracellular calcium signaling pathways that can regulate gene expression, potentially affecting Gpr165. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a tyrosine kinase inhibitor, which may modulate receptor tyrosine kinase signaling and potentially influence Gpr165 expression. | ||||||