GMPR1 Activators
Chemical activators of GMPR1 can play a significant role in its enzyme activity by facilitating its catalytic function in various ways. S-Adenosylmethionine, for instance, acts as a methyl donor in the activation process, potentially altering the conformation of GMPR1 to enhance its active state. The presence of GTP, as a substrate, is indispensable for GMPR1, providing it with phosphate groups necessary for its enzymatic conversion processes. Magnesium ions, supplied by Magnesium Chloride, are crucial cofactors that activate GMPR1 by enabling substrate binding and stabilizing the enzyme's active conformation. Similarly, Mn2+ ions can bind to the active site of GMPR1, participating directly in the catalytic reaction, thus serving as an activator.
Furthermore, ions like K+ and Na+ play pivotal roles in maintaining the electrostatic balance and charge distribution which is essential for the proper folding and activity of GMPR1. Zn2+ ions may also interact with GMPR1, possibly inducing a structural change leading to its activation. Ammonium chloride contributes to maintaining the pH balance within the cell, thereby optimizing the conditions for GMPR1's catalytic action. Enzymatic activity is also influenced by the cellular redox state; FAD can help maintain a reduced environment that ensures the thiol groups of GMPR1 remain in a state conducive to activity. Additionally, the availability of substrates like L-Arginine, which is associated with the production of signaling molecules affecting protein function, and L-Glutamine, which is involved in nucleotide biosynthesis, can support GMPR1 activation. D-Ribose 5-phosphate also plays a part by contributing to the generation of guanine nucleotide precursors, ensuring a steady supply of substrate for GMPR1 enzymatic reactions.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ademetionine | 29908-03-0 | sc-278677 sc-278677A | 100 mg 1 g | $180.00 $655.00 | 2 | |
S-Adenosylmethionine (SAMe) is a cofactor in methyltransferase reactions. By donating methyl groups, it can activate GMPR1 by methylating adjacent amino acids, which may change the conformation of GMPR1 to its active state. | ||||||
Guanosine-5′-Triphosphate, Disodium salt | 86-01-1 | sc-507564 | 1 g | $700.00 | ||
Guanosine-5'-triphosphate (GTP) serves as a substrate for GMPR1. The availability of GTP can enhance the activity of GMPR1 by providing the necessary phosphate groups for the conversion process that GMPR1 catalyzes. | ||||||
Magnesium chloride | 7786-30-3 | sc-255260C sc-255260B sc-255260 sc-255260A | 10 g 25 g 100 g 500 g | $27.00 $34.00 $47.00 $123.00 | 2 | |
Magnesium Chloride provides Mg2+ ions, which are essential cofactors for many enzymes, including GMPR1. The presence of Mg2+ ions can activate GMPR1 by facilitating the proper binding of substrates and stabilization of the enzyme's active configuration. | ||||||
Potassium | 7440-09-7 | sc-253297 | 1 g | $122.00 | ||
Potassium ions can influence the electrostatic environment of proteins and may assist in the proper folding and activity of GMPR1. The presence of K+ ions can therefore activate GMPR1 by promoting its catalytic function. | ||||||
Ammonium Chloride | 12125-02-9 | sc-202936 sc-202936A sc-202936B | 25 g 500 g 2.5 kg | $38.00 $54.00 $147.00 | 4 | |
Ammonium chloride can contribute to the ionic balance and pH stabilization within the cell. A stable pH is crucial for enzyme activity, and thus NH4Cl can activate GMPR1 by maintaining an optimal pH for its catalytic activity. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc ions are known to be cofactors for various enzymes. For GMPR1, Zn2+ might interact with the protein structure to induce a conformational change that activates the enzyme. | ||||||
L-Arginine | 74-79-3 | sc-391657B sc-391657 sc-391657A sc-391657C sc-391657D | 5 g 25 g 100 g 500 g 1 kg | $20.00 $30.00 $60.00 $215.00 $345.00 | 2 | |
L-Arginine can serve as a precursor for the synthesis of nitric oxide, a signaling molecule that can affect enzyme activity. The production of nitric oxide can lead to post-translational modifications of proteins, including GMPR1, thus activating the enzyme. | ||||||
L-Glutamine | 56-85-9 | sc-391013 sc-391013C sc-391013A sc-391013D sc-391013B | 100 g 250 g 1 kg 5 kg 10 kg | $36.00 $46.00 $97.00 $372.00 $719.00 | 2 | |
L-Glutamine can serve as an amino acid donor for various biosynthetic processes. By contributing to nucleotide biosynthesis, it can maintain a pool of guanine nucleotides, indirectly supporting the substrate availability for GMPR1 activation. | ||||||